Abstract：
There has been a rapid increase in the number of human adenovirus type 7 (HAdV-7) and invasive pulmonary fungal infections (IPFIs) co-infection.
In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs.
Among the 143 patients, 35 cases were co-infected with IPFIs. Others were assigned to the control group (n Z 108). Patients wereprone to be complicated with respiratory failure, heart failure and hemophagocytic syndromein IPFIs group. Thirty-one species of fungi were detected in the IPFIs group, among whichAspergillus was the most common species. Compared to control group, patients had lowerlevels of WBC, CD3þ T lymphocyte counts and CD19þ B lymphocyte counts in IPFIs group.
Aspergillus is the most common species in IPFIs combined with severe HAdV-7 pneumonia. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, we should predict the occurrence of IPFIs when there is multi-system dysfunction and the reduction of CD3+ T lymphocyte counts and CD19+ B lymphocyte counts in course of their disease.
In this study, we included patients with confirmed HAdV-7 infection during the period from 2018 to 2019 to explore clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs.
Among the 143 patients, 35 cases were co-infected with IPFIs. Others were assigned to the control group (n Z 108). Patients wereprone to be complicated with respiratory failure, heart failure and hemophagocytic syndromein IPFIs group. Thirty-one species of fungi were detected in the IPFIs group, among whichAspergillus was the most common species. Compared to control group, patients had lowerlevels of WBC, CD3þ T lymphocyte counts and CD19þ B lymphocyte counts in IPFIs group.
Aspergillus is the most common species in IPFIs combined with severe HAdV-7 pneumonia. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, we should predict the occurrence of IPFIs when there is multi-system dysfunction and the reduction of CD3+ T lymphocyte counts and CD19+ B lymphocyte counts in course of their disease.
摘要：
人类腺病毒7型（HAdV-7）和侵袭性肺真菌感染（IPFI）共感染的数量迅速增加。
在这项研究中,我们纳入了2018年至2019年期间确诊为HAdV-7感染的患者,以探讨重症HAdV-7肺炎合并IPFI的临床特征.
在143名患者中，35例与IPFI共感染。其他人被分配到对照组(nZ108)。患者容易并发呼吸衰竭,心力衰竭和噬血细胞综合征在IPFIs组。在IPFI组中检测到31种真菌，其中曲霉菌是最常见的物种。与对照组相比,患者白细胞水平较低，IPFIs组的CD3+T淋巴细胞计数和CD19+B淋巴细胞计数。
曲霉是IPFI合并严重HAdV-7肺炎的最常见物种。对于年龄较小的患有严重HAdV-7肺炎的儿童，有很长的病程，住进了重症监护室,当多系统功能障碍以及疾病过程中CD3T淋巴细胞计数和CD19B淋巴细胞计数减少时，我们应预测IPFI的发生。
在这项研究中,我们纳入了2018年至2019年期间确诊为HAdV-7感染的患者,以探讨重症HAdV-7肺炎合并IPFI的临床特征.
在143名患者中，35例与IPFI共感染。其他人被分配到对照组(nZ108)。患者容易并发呼吸衰竭,心力衰竭和噬血细胞综合征在IPFIs组。在IPFI组中检测到31种真菌，其中曲霉菌是最常见的物种。与对照组相比,患者白细胞水平较低，IPFIs组的CD3+T淋巴细胞计数和CD19+B淋巴细胞计数。
曲霉是IPFI合并严重HAdV-7肺炎的最常见物种。对于年龄较小的患有严重HAdV-7肺炎的儿童，有很长的病程，住进了重症监护室,当多系统功能障碍以及疾病过程中CD3T淋巴细胞计数和CD19B淋巴细胞计数减少时，我们应预测IPFI的发生。
