Abstract：
Human has used plants to treat many civilisation diseases for thousands of years. Examples include reserpine (hypertension therapy), digoxin (myocardial diseases), vinblastine and vincristine (cancers), and opioids (palliative treatment). Plants are a rich source of natural metabolites with multiple biological activities, and the use of modern approaches and tools allowed finally for more effective bioprospecting. The new phytochemicals are hyaluronidase (Hyal) inhibitors, which could serve as anti-cancer drugs, male contraceptives, and an antidote against venoms. In turn, tyrosinase inhibitors can be used in cosmetics/pharmaceuticals as whitening agents and to treat skin pigmentation disorders. However, the activity of these inhibitors is stricte dependent on their structure and the presence of the chemical groups, e.g. carbonyl or hydroxyl. This review aims to provide comprehensive and in-depth evidence related to the anti-tyrosinase and anti-Hyal activity of phytochemicals as well as confirming their efficiency and future perspectives.
摘要：
几千年来，人类一直在用植物治疗许多文明疾病。例子包括利血平（高血压治疗），地高辛（心肌疾病），长春碱和长春新碱（癌症），和阿片类药物（姑息治疗）。植物是具有多种生物活性的天然代谢产物的丰富来源,现代方法和工具的使用最终允许更有效的生物勘探。新的植物化学物质是透明质酸酶（Hyal）抑制剂，可以作为抗癌药物，男性避孕药,和毒液的解毒剂.反过来,酪氨酸酶抑制剂可用于化妆品/药物中作为增白剂和治疗皮肤色素沉着病症。然而,这些抑制剂的活性严格取决于它们的结构和化学基团的存在，例如羰基或羟基。这篇综述旨在提供与植物化学物质的抗酪氨酸酶和抗Hyal活性有关的全面而深入的证据，并确认其效率和未来前景。
