Abstract：
Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene expression contribute to a given phenotype. The study of CT in hematological diseases revealed chromosome position as an important factor for specific chromosome translocations. In this review, we highlight the history of CT theory, current knowledge on possible clinical applications of CT analysis, and the impact of CT in the development of hematological neoplasia such as multiple myeloma, leukemia, and lymphomas. Accumulating data on nuclear architecture in cancer allow one to propose the three-dimensional nuclear genomic landscape as a novel cancer biomarker for the future.
摘要：
染色体在指定为染色体区域(CT)的不同核区中组织。CT的结构形成是染色质包装和组织的结果，最终影响细胞功能。染色体定位可以识别基因组组织的结构特征，特别是对于基因表达变化导致特定表型的疾病。CT在血液病中的研究表明，染色体位置是特定染色体易位的重要因素。在这次审查中,我们强调CT理论的历史，关于CT分析可能的临床应用的最新知识，以及CT对多发性骨髓瘤等血液肿瘤发展的影响，白血病,和淋巴瘤。关于癌症中核结构的积累数据允许人们提出三维核基因组景观作为未来的新型癌症生物标志物。
