The authors\' cytopathology files were searched for PLPS with histopathologic verification. FNA biopsy smears were performed via standard techniques.
Twenty cases from 20 patients (male/female ratio, 2.3/1; age range, 22-77 years; mean age, 58 years) met the inclusion criteria. All had tissue confirmation. Biopsy sites included the following: thigh (11 [55%]), upper extremity (4 [20%]), axilla (2 [10%]), neck (1 [5%]), chest wall (1 [5%]), and mediastinum (1 [5%]). Aspirates were from primary (17 [85%]), locally recurrent (2 [10%]), and metastatic neoplasms (1 [5%]). The FNA diagnoses were PLPS (10 [50%]), myxofibrosarcoma (4 [20%]), LPS (2 [10%]), sarcoma (2 [10%]), and high-grade malignant neoplasm (2 [10%]). Smears showed thick cell clusters and dissociated single forms. Pleomorphic, epithelioid, and bizarre cell/nuclear shapes were common. PLBs were absent, rare, or unnoticed in 45%. In 25%, smears dominated by myxoid stroma were diagnosed as high-grade myxofibrosarcoma or myxoid LPS. Ancillary testing performed in 5 cases had limited diagnostic efficacy.
FNA biopsy of PLPS, although able to successfully recognize malignancy, suffers from a sampling bias due to an inability to capture or recognize PLBs in a significant proportion of cases secondary to the heterogeneous composition of this neoplasm.
在作者的细胞病理学文件中搜索具有组织病理学验证的PLPS。通过标准技术进行FNA活检涂片。
20例患者中的20例(男女比例,2.3/1;年龄范围,22-77岁;平均年龄,58年)符合纳入标准。都有组织确认。活检部位包括:大腿(11[55%]),上肢(4[20%]),腋窝(2[10%]),颈部(1[5%]),胸壁(1[5%]),和纵隔(1[5%])。吸入剂来自初级(17[85%]),局部复发(2[10%]),和转移性肿瘤(1[5%])。FNA诊断为PLPS(10[50%]),粘液纤维肉瘤(4[20%]),LPS(2[10%]),肉瘤(2[10%]),和高级别恶性肿瘤(2[10%])。涂片显示厚细胞簇和解离的单一形式。多态,上皮样,奇怪的细胞/核形状很常见。PLB缺席,罕见,或未被注意到的45%。在25%,以粘液样基质为主的涂片被诊断为高级别粘液纤维肉瘤或粘液样LPS。在5例中进行的辅助测试诊断功效有限。
PLPS的FNA活检,尽管能够成功识别恶性肿瘤,由于无法捕获或识别PLB,因此在很大一部分继发于该肿瘤异质组成的病例中,存在采样偏差。