Abstract：
Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common bone-related adverse event in recent years. We reported 3 bone metastases of patients who developed MRONJ after receiving bisphosphonates therapy. All patients underwent surgical necrotic bone resection combined with leukocyte and platelet-rich fibrin concentrate (L-PRF) therapy. After 6 months of follow-up, no recurrence and adverse event has been observed. This report shows that treatment with necrotic bone resection and L-PRF is an effective therapy and should be considered as an alternative treatment for the management of advanced cases of MRONJ.
摘要：
药物相关的颌骨坏死（MRONJ）是近年来越来越常见的骨相关不良事件。我们报道了3例接受双膦酸盐治疗后发生MRONJ的患者骨转移。所有患者均接受手术坏死骨切除联合白细胞和富血小板纤维蛋白浓缩物（L-PRF）治疗。经过6个月的随访，未观察到复发和不良事件.该报告表明，坏死骨切除和L-PRF治疗是一种有效的治疗方法，应被视为MRONJ晚期病例的替代治疗方法。
