{Reference Type}: Case Reports
{Title}: Osteonecrosis of the jaw induced by bisphosphonates therapy in bone metastases patient: Case report and literature review.
{Author}: Hao L;Tian Z;Li S;Yan K;Xue Y;
{Journal}: Oral Oncol
{Volume}: 128
{Issue}: 0
{Year}: 05 2022
{Factor}: 5.972
{DOI}: 10.1016/j.oraloncology.2022.105852
{Abstract}: Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common bone-related adverse event in recent years. We reported 3 bone metastases of patients who developed MRONJ after receiving bisphosphonates therapy. All patients underwent surgical necrotic bone resection combined with leukocyte and platelet-rich fibrin concentrate (L-PRF) therapy. After 6 months of follow-up, no recurrence and adverse event has been observed. This report shows that treatment with necrotic bone resection and L-PRF is an effective therapy and should be considered as an alternative treatment for the management of advanced cases of MRONJ.