%0 Case Reports
%T Osteonecrosis of the jaw induced by bisphosphonates therapy in bone metastases patient: Case report and literature review.
%A Hao L
%A Tian Z
%A Li S
%A Yan K
%A Xue Y
%J Oral Oncol
%V 128
%N 0
%D 05 2022
%M 35439709
%F 5.972
%R 10.1016/j.oraloncology.2022.105852
%X Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common bone-related adverse event in recent years. We reported 3 bone metastases of patients who developed MRONJ after receiving bisphosphonates therapy. All patients underwent surgical necrotic bone resection combined with leukocyte and platelet-rich fibrin concentrate (L-PRF) therapy. After 6 months of follow-up, no recurrence and adverse event has been observed. This report shows that treatment with necrotic bone resection and L-PRF is an effective therapy and should be considered as an alternative treatment for the management of advanced cases of MRONJ.