Abstract：
α-Galactosidases are exoglycosidases that are active on galactose-containing side chains in oligosaccharides, polysaccharides, glycolipids, and glycoproteins. α-Galactosidases are gaining increased interest in human medicine, especially in the enzyme replacement therapy for Fabry\'s disease. α-Galactosidases with regioselectivity toward α-1,3-linked galactose find application in xenotransplantation and blood group transformation. The use of α-galactosidases as a therapeutic agent in alleviating the postprandial symptoms of irritable bowel syndrome is much acclaimed. The excellent therapeutic applications of α-galactosidases have led to an upwelling of worldwide research interventions to identify novel α-galactosidases with improved catalytic efficiency. In addition to these therapeutic applications, α-galactosidases also have interesting applications in the industrial sectors like food, feed, probiotics, sugar, and paper pulp. The current review focuses on the diverse therapeutic applications of α-galactosidases and their prospects.
摘要：
α-半乳糖苷酶是在寡糖中的含半乳糖侧链上有活性的外切糖苷酶,多糖，糖脂,和糖蛋白。α-半乳糖苷酶在人类医学中获得了越来越多的兴趣，特别是在法布里病的酶替代疗法中。对α-1,3-连接的半乳糖具有区域选择性的α-半乳糖苷酶可用于异种移植和血型转化。使用α-半乳糖苷酶作为减轻肠易激综合征的餐后症状的治疗剂是广受好评的。α-半乳糖苷酶的出色治疗应用已导致全球研究干预措施的兴起，以鉴定具有改善的催化效率的新型α-半乳糖苷酶。除了这些治疗应用，α-半乳糖苷酶在食品等工业部门也有有趣的应用，饲料，益生菌，糖,和纸浆。目前的综述集中在α-半乳糖苷酶的各种治疗应用及其前景。
