Abstract：
Cilia are important for the interaction with environments and the proper function of tissues. While the basic structure of cilia is well conserved, ciliated cells have various functions. To understand the distinctive identities of ciliated cells, the identification of cell-specific proteins and its regulation is essential. Here, we report the mechanism that confers a specific identity on IL2 neurons in Caenorhabditis elegans, neurons important for the dauer larva-specific nictation behavior. We show that DAF-19M, an isoform of the sole C. elegans RFX transcription factor DAF-19, heads a regulatory subroutine, regulating target genes through an X-box motif variant under the control of terminal selector proteins UNC-86 and CFI-1 in IL2 neurons. Considering the conservation of DAF-19M module in IL2 neurons for nictation and in male-specific neurons for mating behavior, we propose the existence of an evolutionarily adaptable, hard-wired genetic module for distinct behaviors that share the feature \"recognizing the environment.\"
摘要：
纤毛对于与环境的相互作用和组织的正常功能是重要的。虽然纤毛的基本结构很保守，纤毛细胞具有多种功能。为了了解纤毛细胞的独特身份，细胞特异性蛋白质的鉴定及其调节是必不可少的。这里,我们报道了在秀丽隐杆线虫中赋予IL2神经元特定身份的机制，对dauer幼虫特异性叮咬行为很重要的神经元。我们证明DAF-19M，唯一的C.elegansRFX转录因子DAF-19的同种型，是调节子程序，在IL2神经元中的末端选择蛋白UNC-86和CFI-1的控制下通过X-box基序变体调节靶基因。考虑到IL2神经元中DAF-19M模块的保守性，以及雄性特异性神经元中的交配行为，我们提出了一种进化适应性的存在，硬连线遗传模块，用于共享“识别环境”的不同行为。\"
