Abstract：
The ameliorating effect of risperidone on apomorphine-induced stereotyped behavior and inhibition of auditory sensory gating was investigated using rhesus monkeys. The total duration of the stereotyped behavior observed in the control group was 43.7 ± 23.0 s (n = 3) between 10 and 25 min after vehicle administration, whereas the duration in the apomorphine-treated (0.1 or 0.15 mg/kg i.m., n = 3) group was observed to be significantly prolonged to 413.0 ± 150.6 s. Administration of 0.01, 0.03, 0.1 mg/kg of risperidone 60 min before apomorphine, significantly reduced the duration of this apomorphine-induced stereotyped behavior to 327 ± 104.9 s (n = 3), 8.3 ± 4.2 s (n = 3), and 0.0 ± × 0.0 s (n = 3, t-test: p < 0.05), respectively. Next, the auditory sensory gating test/conditioning (T/C) ratio was used as a bio-marker. The T/C ratio was 0.598 ± 0.0802 in the vehicle-administered control group (n = 4) and was significantly increased to 2.098 ± 0.254 (n = 4) by apomorphine (0.15 mg/kg, i.m.). Administering of risperidone (0.1 mg/kg, s.c.) 30 min before apomorphine treatment significantly restricted the T/C ratio to 0.571 ± 0.0886 (n = 4), compared to the T/C ratio in the vehicle-administered control group. The above results demonstrate, not only behaviorally but also electrophysiologically, the ameliorating effect of risperidone on the induction of schizophrenia-like symptoms by apomorphine in non-human primates.
摘要：
使用恒河猴研究了利培酮对阿朴吗啡诱导的刻板行为和听觉感觉门控抑制的改善作用。在对照组中观察到的定型行为的总持续时间为43.7±23.0s（n=3），而阿朴吗啡治疗的持续时间（0.1或0.15mg/kgi.m.，n=3)组观察到显著延长至413.0±150.6s。阿扑吗啡前60分钟给予0.01、0.03、0.1mg/kg利培酮,将阿朴吗啡诱导的定型行为的持续时间显着减少到327±104.9s（n=3），8.3±4.2s(n=3)，和0.0±0.0s(n=3，t检验：p<0.05)，分别。接下来,听觉感觉门控测试/条件调节（T/C）比用作生物标记。在施用载体的对照组（n=4）中，T/C比为0.598±0.0802，并且通过阿朴吗啡（0.15mg/kg，i.m.).利培酮（0.1mg/kg，s.c.）阿扑吗啡治疗前30分钟显着限制T/C比为0.571±0.0886（n=4），与施用载体的对照组的T/C比率相比。以上结果表明,不仅在行为上，而且在电生理上，利培酮对阿朴吗啡在非人灵长类动物中诱导精神分裂症样症状的改善作用。
