Abstract：
BACKGROUND: Resistant ovary syndrome (ROS) is a rare endocrine disorder and there have been few reports of live births by affected patients. As gonadotropin resistance leads immature oocytes, some researchers reported few live births with in vitro maturation (IVM) of oocytes, but IVM is not always successful in ROS patients. Here, we report an original case of ROS, associated with Ig-FSHR in the serum, who achieved a live birth following ovarian stimulation combined with dexamethasone treatment.
METHODS: The 30-year-old woman presented with secondary amenorrhea and infertility. Her serum FSH levels were found to be higher than normal, but in discordance with a normal anti-Müllerian hormone (AMH) level and antral follicle count. Genetic investigation found no mutations potentially affecting FSHR. With reference of previous ROS studies, the patient\'s serum was analyzed for antibodies directed against FSHR and dot blot analysis showed strong reactivity with FSHR. Then, dexamethasone was proposed to the patient, and she successfully became pregnant, finally delivering a healthy girl by caesarean section.
CONCLUSIONS: To our best knowledge, this is the first report of the successful treatment of ROS using ovarian stimulation combined with dexamethasone. In some cases of ROS, high doses of exogenous gonadotropins in combination with immunosuppressive therapy could be an effective approach.
METHODS: The 30-year-old woman presented with secondary amenorrhea and infertility. Her serum FSH levels were found to be higher than normal, but in discordance with a normal anti-Müllerian hormone (AMH) level and antral follicle count. Genetic investigation found no mutations potentially affecting FSHR. With reference of previous ROS studies, the patient\'s serum was analyzed for antibodies directed against FSHR and dot blot analysis showed strong reactivity with FSHR. Then, dexamethasone was proposed to the patient, and she successfully became pregnant, finally delivering a healthy girl by caesarean section.
CONCLUSIONS: To our best knowledge, this is the first report of the successful treatment of ROS using ovarian stimulation combined with dexamethasone. In some cases of ROS, high doses of exogenous gonadotropins in combination with immunosuppressive therapy could be an effective approach.
摘要：
背景：抵抗性卵巢综合征（ROS）是一种罕见的内分泌疾病，很少有关于患病患者活产的报道。由于促性腺激素抗性导致未成熟卵母细胞，一些研究人员报道了很少有卵母细胞体外成熟（IVM）的活产，但在ROS患者中，IVM并不总是成功的。这里,我们报告了一个ROS的原始病例，与血清中的Ig-FSHR相关，卵巢刺激联合地塞米松治疗后实现活产。
方法：30岁女性出现继发性闭经和不孕症。发现她的血清FSH水平高于正常水平，但与正常的抗苗勒管激素（AMH）水平和窦卵泡计数不一致。遗传调查未发现可能影响FSHR的突变。参考以前的ROS研究，分析患者血清中针对FSHR的抗体,斑点印迹分析显示与FSHR的反应性强.然后，向患者推荐了地塞米松，她成功地怀孕了,最终通过剖腹产接生了一个健康的女孩.
结论：据我们所知，这是首次报道卵巢刺激联合地塞米松成功治疗ROS.在某些情况下，ROS大剂量外源性促性腺激素联合免疫抑制治疗可能是一种有效的方法。
方法：30岁女性出现继发性闭经和不孕症。发现她的血清FSH水平高于正常水平，但与正常的抗苗勒管激素（AMH）水平和窦卵泡计数不一致。遗传调查未发现可能影响FSHR的突变。参考以前的ROS研究，分析患者血清中针对FSHR的抗体,斑点印迹分析显示与FSHR的反应性强.然后，向患者推荐了地塞米松，她成功地怀孕了,最终通过剖腹产接生了一个健康的女孩.
结论：据我们所知，这是首次报道卵巢刺激联合地塞米松成功治疗ROS.在某些情况下，ROS大剂量外源性促性腺激素联合免疫抑制治疗可能是一种有效的方法。
