Abstract：
The present study aimed to investigate the association between dietary acid load and the risk of type 2 diabetes (T2D) in Iranian adults.
This was a case-control study including 125 newly diagnosed T2D patients as cases and 190 healthy individuals as controls. A 168-item semi-quantitative food frequency questionnaire was applied to collect the participant\'s dietary intake information. Potential renal acid load (PRAL), net endogenous acid production (NEAP), protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio were derived from the nutrient intake.
We found that higher PRAL and NEAP scores are positively associated with the chance of T2D in the unadjusted model. Such that, when multiple potential confounders were taken into account, participants in the highest tertile of PRAL (OR: 4.37; 95% CI: 1.35-14.18) and NEAP score (OR: 2.24; 95% CI: 1.01-7.03) had a greater risk of T2D. No significant association was found between other indices including total protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio, and T2D risk.
The present findings suggest that high dietary acid load could be associated with the risk of T2D disease.
This was a case-control study including 125 newly diagnosed T2D patients as cases and 190 healthy individuals as controls. A 168-item semi-quantitative food frequency questionnaire was applied to collect the participant\'s dietary intake information. Potential renal acid load (PRAL), net endogenous acid production (NEAP), protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio were derived from the nutrient intake.
We found that higher PRAL and NEAP scores are positively associated with the chance of T2D in the unadjusted model. Such that, when multiple potential confounders were taken into account, participants in the highest tertile of PRAL (OR: 4.37; 95% CI: 1.35-14.18) and NEAP score (OR: 2.24; 95% CI: 1.01-7.03) had a greater risk of T2D. No significant association was found between other indices including total protein/potassium ratio, animal protein/potassium ratio, and plant protein/potassium ratio, and T2D risk.
The present findings suggest that high dietary acid load could be associated with the risk of T2D disease.
摘要：
本研究旨在调查伊朗成年人的饮食酸负荷与2型糖尿病（T2D）风险之间的关系。
这是一项病例对照研究，包括125例新诊断的T2D患者和190例健康个体作为对照。采用168项半定量食物频率问卷收集参与者的饮食摄入信息。潜在的肾脏酸负荷（PRAL），净内源酸产量（NEAP），蛋白质/钾比率，动物蛋白质/钾比率，植物蛋白/钾比来自营养摄入量。
我们发现，在未调整的模型中，较高的PRAL和NEAP评分与T2D的机会呈正相关。这样，当考虑到多个潜在的混杂因素时，PRAL最高三分位数(OR:4.37;95%CI:1.35~14.18)和NEAP评分(OR:2.24;95%CI:1.01~7.03)的参与者患T2D的风险更大.其他指标，包括总蛋白质/钾比率，动物蛋白质/钾比率，和植物蛋白/钾的比例，T2D风险。
目前的研究结果表明，高膳食酸负荷可能与T2D疾病的风险有关。
这是一项病例对照研究，包括125例新诊断的T2D患者和190例健康个体作为对照。采用168项半定量食物频率问卷收集参与者的饮食摄入信息。潜在的肾脏酸负荷（PRAL），净内源酸产量（NEAP），蛋白质/钾比率，动物蛋白质/钾比率，植物蛋白/钾比来自营养摄入量。
我们发现，在未调整的模型中，较高的PRAL和NEAP评分与T2D的机会呈正相关。这样，当考虑到多个潜在的混杂因素时，PRAL最高三分位数(OR:4.37;95%CI:1.35~14.18)和NEAP评分(OR:2.24;95%CI:1.01~7.03)的参与者患T2D的风险更大.其他指标，包括总蛋白质/钾比率，动物蛋白质/钾比率，和植物蛋白/钾的比例，T2D风险。
目前的研究结果表明，高膳食酸负荷可能与T2D疾病的风险有关。
