关键词： 24-h ABPM, 24-hour ambulatory blood pressure monitoring BP, blood pressure Cryo-RDN, renal denervation with cryoablation DBP, diastolic blood pressure Fr, French NE, norepinephrine OBP, office blood pressure RDN, renal denervation RH, resistant hypertension SBP, systolic blood pressure SNS, sympathetic nerve system TH, tyrosine hydroxylase cryoablation eGFR, estimated glomerular filtration rate renal denervation resistant hypertension 24-h ABPM, 24-hour ambulatory blood pressure monitoring BP, blood pressure Cryo-RDN, renal denervation with cryoablation DBP, diastolic blood pressure Fr, French NE, norepinephrine OBP, office blood pressure RDN, renal denervation RH, resistant hypertension SBP, systolic blood pressure SNS, sympathetic nerve system TH, tyrosine hydroxylase cryoablation eGFR, estimated glomerular filtration rate renal denervation resistant hypertension

来  源：   DOI：10.1016/j.jacbts.2021.11.002   PDF(Pubmed)

Abstract：
Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.
摘要：
最近,我们设计了一种使用液氮的冷冻消融（Cryo-RDN）肾脏去神经系统，并证明了其短期安全性和有效性。在这项研究中,我们首先在猪模型中进行了6个月的随访.6个月后，肾交感神经活性保持在明显低于对照组的水平。在顽固性高血压患者中，Cryo-RDN证明了初步的安全性。未检测到肾功能波动和血管相关并发症。此外,随访6个月时，24小时收缩压和舒张压平均下降12.17±8.35mmHg和8.50±3.83mmHg，分别,与它们的基线值进行比较。
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