{Reference Type}: Journal Article
{Title}: Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series.
{Author}: Ji M;Chen H;Shen L;Zhang Y;Yao Z;Wu Y;Xu Y;Ge J;Ji M;Chen H;Shen L;Zhang Y;Yao Z;Wu Y;Xu Y;Ge J;
{Journal}: JACC Basic Transl Sci
{Volume}: 7
{Issue}: 2
{Year}: Feb 2022
{Factor}: 9.531
{DOI}: 10.1016/j.jacbts.2021.11.002
{Abstract}: Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.