%0 Journal Article
%T Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series.
%A Ji M
%A Chen H
%A Shen L
%A Zhang Y
%A Yao Z
%A Wu Y
%A Xu Y
%A Ge J
%A Ji M
%A Chen H
%A Shen L
%A Zhang Y
%A Yao Z
%A Wu Y
%A Xu Y
%A Ge J
%J JACC Basic Transl Sci
%V 7
%N 2
%D Feb 2022
%M 35257036
%F 9.531
%R 10.1016/j.jacbts.2021.11.002
%X Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.