关键词: Atypical pathogens adult community-acquired pneumonia antibiotic coverage cap chlamydia legionella mycoplasma Atypical pathogens adult community-acquired pneumonia antibiotic coverage cap chlamydia legionella mycoplasma

Mesh : Adult Anti-Bacterial Agents / therapeutic use Community-Acquired Infections / drug therapy epidemiology Humans India / epidemiology Mycoplasma pneumoniae Pneumonia, Bacterial / diagnosis drug therapy epidemiology Seasons

来  源:   DOI:10.1177/00494755221080587

Abstract:
Atypical agents such as Mycoplasma, Legionella, Chlamydia species, and Coxiella burnetii (Q-fever agent) are responsible for some adult community-acquired pneumonia (CAP). Insufficient studies on this topic can be blamed for the failure to include atypical pathogens in empirical management. We followed adult CAP cases for two years, and samples (respiratory and serum) were tested by culture, ELISA (IgM, IgG, and IgA), and PCR. A risk factor analysis was performed. Overall in 21.3% adult CAP patients, atypical agents found were Mycoplasma pneumoniae (51.5%), Legionella pneumophila (28.8%), and Chlamydophila pneumoniae (19.7%). However, amongst patients <60 years of age and in the summer season, the proportion of atypical agents increased significantly. There is thus a need to re-examine empirical antibiotic regimes.
摘要:
非典型病原体,如支原体,军团菌,衣原体种类,和伯氏柯西氏菌(Q热剂)是一些成人社区获得性肺炎(CAP)的原因。有关该主题的研究不足可归咎于未能将非典型病原体纳入经验管理。我们追踪成人CAP病例两年,和样品(呼吸道和血清)通过培养进行测试,ELISA(IgM,IgG,和IgA),和PCR。进行了危险因素分析。总体而言,21.3%的成人CAP患者,发现的非典型病原体是肺炎支原体(51.5%),嗜肺军团菌(28.8%),肺炎衣原体(19.7%)。然而,在年龄<60岁和夏季的患者中,非典型药物的比例显著增加.因此,需要重新审查经验性抗生素方案。
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