PDF(Pubmed)
Abstract：
Methamphetamine (MA) use affects the brain structure and function. However, no studies have investigated the relationship between changes in regional homogeneity (ReHo) and impulsivity in MA dependent individuals (MADs). The aim of this study was to investigate the changes of brain activity under resting state in MADs and their relationship to impulsivity using ReHo method. Functional magnetic resonance imaging (fMRI) was performed to collect data from 46 MADs and 44 healthy controls (HCs) under resting state. ReHo method was used to investigate the differences in average ReHo values between the two groups. The ReHo values abnormalities of the brain regions found in inter-group comparisons were extracted and correlated with impulsivity. Compared to the HCs, MADs showed significant increased ReHo values in the bilateral striatum, while the ReHo values of the bilateral precentral gyrus and the bilateral postcentral gyrus decreased significantly. The ReHo values of the left precentral gyrus were negatively correlated with the BIS-attention, BIS-motor, and BIS-nonplanning subscale scores, while the ReHo values of the postcentral gyrus were only negatively correlated with the BIS-motor subscale scores in MADs. The abnormal spontaneous brain activity in the resting state of MADs revealed in this study may further improve our understanding of the neuro-matrix of MADs impulse control dysfunction and may help us to explore the neuropathological mechanism of MADs related dysfunction and rehabilitation.
摘要：
甲基苯丙胺（MA）的使用会影响大脑的结构和功能。然而,尚无研究调查MA依赖个体（MAD）的区域同质性（ReHo）变化与冲动性之间的关系。本研究的目的是使用ReHo方法研究MADs在静息状态下脑活动的变化及其与冲动的关系。在静息状态下进行功能磁共振成像（fMRI）以从46个MAD和44个健康对照（HC）收集数据。采用ReHo法研究两组间平均ReHo值的差异。提取了在组间比较中发现的大脑区域的ReHo值异常，并将其与冲动相关联。与HC相比，MAD显示双侧纹状体的ReHo值显着增加，而双侧中央前回和双侧中央后回的ReHo值显着下降。左中央前回的ReHo值与BIS注意力呈负相关,BIS电机,和BIS非计划子量表得分，而中央回的ReHo值仅与MAD中的BIS运动子量表得分呈负相关。本研究揭示的MADs在静息状态下的自发脑活动异常，可能会进一步提高我们对MADs冲动控制功能障碍的神经基质的认识，并可能有助于我们探索MADs相关功能障碍和康复的神经病理学机制。
