■抑郁症状是强迫症(OCD)患者中最常见的合并症。本研究的目的是研究伴有抑郁症状的OCD患者的静息状态神经活动的动态特征。
■我们招募了29名患有抑郁症状的强迫症患者,21名没有抑郁症状的强迫症患者,和27个健康对照,并通过结构和功能磁共振成像(fMRI)收集数据。我们使用低频波动的动态幅度(dALFF)和支持向量机(SVM)技术分析了fMRI结果。
■与无抑郁症状的强迫症患者相比,患有抑郁症状的强迫症患者在左前肌表现出dALFF升高,在右内侧额回表现出dALFF降低。支持向量机表明,在左前肌和右内侧额回中的异常dALFF值的整合导致80%的总体准确性,79%的灵敏度,在强迫症患者中检测抑郁症状的特异性为100%。
■因此,我们的研究表明,有抑郁症状的强迫症患者在静息状态下表现出具有独特动态特征的神经活动。因此,左前肌和右额内侧回的异常dALFF值可用于识别强迫症患者的抑郁症状。
UNASSIGNED: Depressive symptoms are the most prevalent comorbidity in individuals with obsessive-compulsive disorder (OCD). The objective of this study was to investigate the dynamic characteristics of resting-state neural activities in OCD patients with depressive symptoms.
UNASSIGNED: We recruited 29 OCD patients with depressive symptoms, 21 OCD patients without depressive symptoms, and 27 healthy controls, and collected data via structural and functional magnetic resonance imaging (fMRI). We analyzed the fMRI results using the dynamic amplitude of low-frequency fluctuation (dALFF) and support vector machine (SVM) techniques.
UNASSIGNED: Compared with OCD patients without depressive symptoms, OCD patients with depressive symptoms exhibited an increased dALFF in the left precuneus and decreased dALFF in the right medial frontal gyrus. The SVM indicated that the integration of aberrant dALFF values in the left precuneus and right medial frontal gyrus led to an overall accuracy of 80%, a sensitivity of 79%, and a specificity of 100% in detecting depressive symptoms among OCD patients.
UNASSIGNED: Therefore, our study reveals that OCD patients with depressive symptoms display neural activities with unique dynamic characteristics in the resting state. Accordingly, abnormal dALFF values in the left precuneus and right medial frontal gyrus could be used to identify depressive symptoms in OCD patients.