Abstract：
Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized products. An association between a positive clinical history and a strong patch test reaction has been described, but problems with doubtful/irritant reactions have also been reported. Considering the high frequency of relevant positive reactions, the incorporation of Lim-OOHs 0.3% and Lin-OOHs 1% in the baseline series may be justified. Since exposure, sensitization, and elicitation limits of Lim-OOHs and Lin-OOHs in the products still need to be better determined, an assessment of previous exposure, possible sensitizations, and reactions may help to improve the clinical assessment.
摘要：
柠檬烯和芳樟醇是日常产品中使用的最常见的香料萜烯之一。它们是前触觉，形成氢过氧化物(Lim-OOHs，Lin-OOOHs）在皮炎患者中氧化并诱导频繁的斑贴试验阳性反应，然而，它们在欧洲没有例行测试。这篇综述通过询问是否有必要进行过氧化氢贴片测试来评估Lim-OOOHs和Lin-OOHs的当前贴片测试，检查与使用当前可用材料阅读和解释过氧化氢贴片测试结果有关的困难或挑战，并评估其相关性。研究越来越多地指出，在用这些氧化产物连续测试的患者中，阳性反应的百分比很高。已经描述了阳性临床病史和强烈斑贴试验反应之间的关联，但也报道了可疑/刺激性反应的问题。考虑到相关阳性反应的频率很高，在基线系列中加入0.3%的Lim-OOHs和1%的Lin-OOHs可能是合理的.自从曝光以来，致敏,产品中Lim-OOOHs和Lin-OOOHs的引出限制仍需更好地确定，对以前暴露的评估，可能的敏化，和反应可能有助于改善临床评估。
