Abstract：
Parkinson\'s disease (PD) is a common, progressive, and incurable neurodegenerative disease. Pharmacological treatment is the first-line therapy for PD, including carbidopa-levodopa, dopamine agonists. However, some patients respond poorly to medication. For these patients, functional neurosurgical treatment is an important option. Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel, minimally invasive surgical option for patients refractory to drugs. Currently, several important anatomical structures can be targeted by MRgFUS in the treatment of PD. However, there is no uniform standard for target selection. This review summarizes the clinical studies on MRgFUS for PD, focusing on the relationship between different treatment targets and the relieved symptoms, to help clinicians determine the ideal therapeutic target for individual patients. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 4.
摘要：
帕金森病(PD)是一种常见的疾病,进步,和无法治愈的神经退行性疾病。药物治疗是PD的一线治疗，包括卡比多巴-左旋多巴,多巴胺激动剂.然而,有些患者对药物治疗反应不佳。对于这些患者来说,功能神经外科治疗是一种重要的选择。磁共振引导聚焦超声(MRgFUS)是一种新颖的,药物难治性患者的微创手术选择。目前,MRgFUS在PD的治疗中可以靶向几种重要的解剖结构。然而,目标选择没有统一的标准。本文就MRgFUS治疗PD的临床研究作一综述。关注不同治疗目标与缓解症状之间的关系，帮助临床医生为个体患者确定理想的治疗目标。证据级别：5技术效率：第4阶段。
