Atypical case of retinopathy of prematurity with candle wax-like preretinal deposits and its surprising response to intravitreal antivascular endothelial growth factor.

蜡烛蜡样视网膜前沉积早产儿视网膜病变的非典型病例及其对玻璃体内抗血管内皮生长因子的惊人反应。

• 发表时间: Jan 2022 17
• 来源期刊: BMJ Case Rep
• DOI: 10.1136/bcr-2021-244998
• PMID: 35039342
• 文章类型: Case Reports
• 作者列表: Shah MS,Padhy SK,Sahu S,Padhi TR

关键词: neonatal health; retina

Mesh: Angiogenesis Inhibitors / therapeutic use; Bevacizumab / therapeutic use; Endothelial Growth Factors / therapeutic use; Gestational Age; Humans; Infant; Infant, Newborn; Intravitreal Injections; Laser Coagulation; Retinopathy of Prematurity / drug therapy surgery; Retrospective Studies

Abstract

Presented here is a case of hybrid retinopathy of prematurity (ROP) with features of both aggressive posterior ROP and ridge-like staged ROP with extensive candle wax-like preretinal deposits plastered on the surface of the retina from optic disc to vascular-avascular junction at a postmenstrual age (PMA) of 34 weeks. The baby was too sick for laser photocoagulation and so underwent intravitreal bevacizumab at half adult doses in both eyes. The deposits melted dramatically within 1-2 weeks of antivascular endothelial growth factor injection without any signs of recurrence till the last visit at 58 weeks of PMA.

摘要

这里介绍的是一例早产儿混合性视网膜病变（ROP），其特征是积极的后部ROP和脊状分期ROP，从视盘到血管的视网膜表面贴有大量的蜡烛蜡状视网膜前沉积物。月经后年龄（PMA）为34周。婴儿病重，无法进行激光光凝，因此双眼接受了一半成人剂量的玻璃体内贝伐单抗。在注射抗血管内皮生长因子的1-2周内，沉积物急剧融化，直到PMA58周的最后一次就诊为止，没有任何复发迹象。