PDF(Pubmed)
Abstract：
Objective: Auditory P50 gating changed might be a neurophysiological biomarker of the diagnosis of Mild Cognitive Impairment (MCI). We aimed to determine the impact of MCI in auditory P50 gating. Methods: All recruited participants completed structured questionnaires and finished auditory P50 gating measure. Results: A total of 20 MCI patients and 17 controls had been recruited. MCI patients had a significant higher reduction of P50 gating at Fz site, when compared to controls (1.21 ± .68 vs .66 ± .37, P = .00). Zero point five was the best cut off point to distinguish MCI and control of auditory P50 gating S2/S1 at Fz site. The P50 average amplitude at Pz site in MCI patients was significantly higher than controls (2.62 ± 1.20 vs 1.70 ± .74, P = .01). Conclusion: MCI patients might have impaired the ability of inhibiting the repeated stimulus.
摘要：
目的：听觉P50门控改变可能是诊断轻度认知损害（MCI）的神经生理学生物标志物。我们旨在确定MCI在听觉P50门控中的影响。方法：所有招募的参与者完成结构化问卷并完成听觉P50门控测量。结果：共招募了20名MCI患者和17名对照。MCI患者在Fz部位的P50门控明显减少，与对照组相比（1.21±.68vs.66±.37，P=.00）。零点五是区分MCI和在Fz位点门控S2/S1的听觉P50控制的最佳截止点。MCI患者Pz部位的P50平均振幅明显高于对照组（2.62±1.20vs1.70±0.74，P=0.01）。结论：MCI患者对重复刺激的抑制能力可能有损害。
