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Nrf2 / HO - 1 信号的激活 : 中药通过保护血管内皮细胞免受氧化应激来治疗动脉粥样硬化的重要分子机制。
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关键词:
7-HMR, (−)-7(S)-hydroxymatairesinol
ADH, andrographolide
AGE, advanced glycation end product
AMP, Athyrium Multidentatum
APV, aqueous extracts of Prunella Vulgaris
ARE, antioxidant reaction elements
AS, atherosclerosis
ASD-IV, Astragaloside IV
ASP, Angelica sinensis polysaccharide
ASTP, Astragalus polysacharin
Akt, protein kinase B
Ang, Angiotensin
ApoE, apolipoprotein E
Atherosclerosis
BAECs, bovine artery endothelial cells
BBR, Berberine
BITC, benzyl isothiocyanate
C3G, Cyanidin-3-O-glucoside
CINM, Cinnamaldehyde
CNC, Cap'n'collar
CREB, cAMP-response element binding protein
CVDs, cardiovascular diseases
CVRF, cardiovascular risk factors
DMY, Dihydromyricetin
ECC, (−)-Epicatechin
ECs, endothelial cells
EGCG, epigallocatechin-3-O-gallate
ERK, extracellular regulated protein kinases
ET, endothelin
EXS, Xanthoceras sorbifolia
FFA, Fatty Acids
GPx, Glutathione peroxidase
GSD Rg1, Ginsenoside Rg1
GTE, Ganoderma tsugae extracts
Gau A, Glaucocalyxin A
HAMS, human anthocyanin medicated serum
HG, high glucose
HIF-1, Hypoxia-inducible factor 1
HO-1, heme oxygenase
HUVECs, human umbilical vein endothelial cells
HXC, Huoxue capsule
Hcy, Homocysteine
Herbal medicine
ICAM, intercellular adhesion molecule
IL, interleukin
KGRE, extracts of KGR
KRG, Korean red ginseng
Keap1, kelch-like epichlorohydrin-related proteins
LWDH, Liuwei-Dihuang pill
MA, maslinic acid
MAPKK, mitogen-activated protein kinase kinase
MAPKs, mitogen-activated protein kinases
MCGA3, 3-O-caffeoyl-1-methylquinic acid
MCP-1, monocyte chemotactic protein 1
MMPs, matrix metalloproteinases
Molecular mechanism
NAF, Nepeta Angustifolia
NF-κB, nuclear factor kappa-B
NG, naringenin
NQO1, NAD(P)H: quinone oxidoreductase
Nrf2, nuclear factor erythroid-2 related factor 2
Nrf2/HO-1 signaling
OA, Oleanolic acid
OMT, Oxymatrine
OX-LDL, oxidized low density lipoprotein
Oxidative stress
PA, Palmitate
PAA, Pachymic acid
PAI-1, plasminogen activator Inhibitor-1
PEITC, phenethyl isocyanate
PI3K, phosphatidylinositol 3 kinase
PKC, protein kinase C
PT, Pterostilbene
RBPC, phenolic extracts derived from rice bran
ROS, reactive oxygen species
SAL, Salidroside
SFN, sulforaphane
SMT, Samul-Tang Tang
SOD, superoxide dismutase
Sal B, salvianolic acid B
SchB, Schisandrin B
TCM, traditional Chinese medicine
TNF, tumor necrosis factor
TXA2, Thromboxane A2
TrxR1, thioredoxin reductase-1
US, uraemic serum
VA, Vanillic acid
VCAM, vascular cell adhesion molecule
VEC, vascular endothelial cells
VEI, vascular endothelial injury
Vascular endothelial cells
XAG, xanthoangelol
XXT, Xueshuan Xinmaining Tablet
Z-Lig, Z-ligustilide
eNOS, endothelial NO synthase
Mesh :
Atherosclerosis / drug therapy
Endothelial Cells / metabolism
Heme Oxygenase-1 / metabolism
Herbal Medicine
Humans
NF-E2-Related Factor 2 / metabolism
Oxidative Stress
Pharmaceutical Preparations
来 源:
DOI:10.1016/j.jare.2021.06.023
PDF(Sci-hub)
PDF(Pubmed)
Abstract:
Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury.
This paper aimed to summarized the natural monomers/extracts that potentially exert protective effects against oxidative stress in ECs.
A literature search was carried out regarding our topic with the keywords of \"atherosclerosis\" or \"Nrf2/HO-1\" or \"vascular endothelial cells\" or \"oxidative stress\" or \"Herbal medicine\" or \"natural products\" or \"natural extracts\" or \"natural compounds\" or \"traditional Chinese medicines\" based on classic books of herbal medicine and scientific databases including Pubmed, SciFinder, Scopus, the Web of Science, GoogleScholar, BaiduScholar, and others. Then, we analyzed the possible molecular mechanisms for different types of natural compounds in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress. In addition, perspectives for possible future studies are discussed.
These agents with protective effects against oxidative stress in ECs mainly include phenylpropanoids, flavonoids, terpenoids, and alkaloids. Most of these agents alleviate cell apoptosis in ECs due to oxidative stress, and the mechanisms are related to Nrf2/HO-1 signaling activation. However, despite continued progress in research on various aspects of natural agents exerting protective effects against EC injury by activating Nrf2/HO-1 signaling, the development of new drugs for the treatment of atherosclerosis (AS) and other CVDs based on these agents will require more detailed preclinical and clinical studies.
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1. We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
摘要:
最近,Nrf2/HO-1作为细胞内防御氧化应激的主要调控途径受到广泛关注,被认为是减轻内皮细胞损伤的理想靶点。
本文旨在总结在ECs中潜在发挥抗氧化应激保护作用的天然单体/提取物。
对我们的主题进行了文献检索,关键词为“动脉粥样硬化”或“Nrf2/HO-1”或“血管内皮细胞”或“氧化应激”或“草药”或“天然产物”或“天然提取物”或“天然化合物”或“中药”,基于草药经典书籍和科学数据库,包括Pubmed,SciFinder,Scopus,WebofScience,GoogleScholar,BaiduScholar,和其他人。然后,我们分析了不同类型的天然化合物通过保护血管内皮细胞免受氧化应激来治疗动脉粥样硬化的可能分子机制。此外,讨论了未来可能的研究前景。
这些在ECs中对氧化应激具有保护作用的药物主要包括苯丙素类化合物,黄酮类化合物,萜类化合物,和生物碱。这些药物中的大多数缓解了由于氧化应激导致的ECs细胞凋亡,并且该机制与Nrf2/HO-1信令激活有关。然而,尽管通过激活Nrf2/HO-1信号发挥针对EC损伤的保护作用的天然药物的各个方面的研究不断取得进展,基于这些药物开发治疗动脉粥样硬化(AS)和其他心血管疾病的新药需要更详细的临床前和临床研究.
我们的本文提供了通过激活Nrf2/HO-1对ECs抵抗氧化应激具有保护活性的天然试剂的最新信息。我们希望这篇综述将为进一步开发用于治疗AS和其他CVD的天然药物的新型候选药物提供一些方向。