PDF(Pubmed)
Abstract：
BACKGROUND: Drug-induced valvular heart disease (DI-VHD) is a well-defined condition associated with specific pathology features. However, clinical presentations may broadly vary and thereby make DI-VHD diagnosis more challenging.
METHODS: We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.
CONCLUSIONS: Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.
METHODS: We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.
CONCLUSIONS: Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.
摘要：
背景：药物诱发的瓣膜性心脏病（DI-VHD）是一种明确定义的与特定病理特征相关的疾病。然而,临床表现可能差异很大,从而使DI-VHD诊断更具挑战性.
方法：我们报告了两名有benfluorex用药史的患者，发展为广泛的二尖瓣钙化病变，并演变为干酪样坏死。
结论：对这两名最初有典型DI-VHD发现的患者进行了几年的前瞻性随访，提供了广泛钙化和随后的干酪样坏死的监测证据。这些报告表明钙化性心脏损伤与benfluorex暴露之间存在联系。在这个晚期阶段，DI-VHD的诊断可能会被忽视。
方法：我们报告了两名有benfluorex用药史的患者，发展为广泛的二尖瓣钙化病变，并演变为干酪样坏死。
结论：对这两名最初有典型DI-VHD发现的患者进行了几年的前瞻性随访，提供了广泛钙化和随后的干酪样坏死的监测证据。这些报告表明钙化性心脏损伤与benfluorex暴露之间存在联系。在这个晚期阶段，DI-VHD的诊断可能会被忽视。
