METHODS: We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.
CONCLUSIONS: Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.
方法:我们报告了两名有benfluorex用药史的患者,发展为广泛的二尖瓣钙化病变,并演变为干酪样坏死。
结论:对这两名最初有典型DI-VHD发现的患者进行了几年的前瞻性随访,提供了广泛钙化和随后的干酪样坏死的监测证据。这些报告表明钙化性心脏损伤与benfluorex暴露之间存在联系。在这个晚期阶段,DI-VHD的诊断可能会被忽视。