{Reference Type}: Case Reports
{Title}: Caseous necrosis of the mitral annulus: a new feature of drug-induced valvular heart disease? Case series.
{Author}: Leblon T;Riolet C;Ennezat P;Marechaux S;
{Journal}: Eur Heart J Case Rep
{Volume}: 6
{Issue}: 1
{Year}: Jan 2022
暂无{DOI}: 10.1093/ehjcr/ytab516
{Abstract}: <B>BACKGROUND: </B>Drug-induced valvular heart disease (DI-VHD) is a well-defined condition associated with specific pathology features. However, clinical presentations may broadly vary and thereby make DI-VHD diagnosis more challenging.<BR><B>METHODS: </B>We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.<BR><B>CONCLUSIONS: </B>Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.