%0 Case Reports
%T Caseous necrosis of the mitral annulus: a new feature of drug-induced valvular heart disease? Case series.
%A Leblon T
%A Riolet C
%A Ennezat P
%A Marechaux S
%J Eur Heart J Case Rep
%V 6
%N 1
%D Jan 2022
%M 34993414
暂无%R 10.1093/ehjcr/ytab516
%X <B>BACKGROUND: </B>Drug-induced valvular heart disease (DI-VHD) is a well-defined condition associated with specific pathology features. However, clinical presentations may broadly vary and thereby make DI-VHD diagnosis more challenging.<BR><B>METHODS: </B>We report two patients with a history of benfluorex administration, who developed extensive mitral calcific lesions which evolved towards caseous necrosis.<BR><B>CONCLUSIONS: </B>Prospective follow-up over several years of these two patients who initially had typical DI-VHD findings provided monitoring evidence of extensive calcifications and subsequent caseous necrosis. These reports suggest a link between calcific heart injury and benfluorex exposure. The diagnosis of DI-VHD may be overlooked at this late stage.