关键词： AMP, antimicrobial peptide BD, β-defensin BMI, body mass index DC, dendritic cell DCD, dermcidin GSC, γ-secretase complex HS, hidradenitis suppurativa HiSCR, hidradenitis suppurativa clinical response IBD, inflammatory bowel disease IHS4, International Hidradenitis Suppurativa Severity Score System KC, keratinocyte MMP, matrix metalloproteinase NET, neutrophil extracellular traps NMSC, nonmelanoma skin cancer PG, pyoderma gangrenosum RCT, randomized controlled trial SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis TLR, toll-like receptor Th, T helper type iNOS, inducible nitric oxide synthase pDC, plasmacytoid dendritic cell AMP, antimicrobial peptide BD, β-defensin BMI, body mass index DC, dendritic cell DCD, dermcidin GSC, γ-secretase complex HS, hidradenitis suppurativa HiSCR, hidradenitis suppurativa clinical response IBD, inflammatory bowel disease IHS4, International Hidradenitis Suppurativa Severity Score System KC, keratinocyte MMP, matrix metalloproteinase NET, neutrophil extracellular traps NMSC, nonmelanoma skin cancer PG, pyoderma gangrenosum RCT, randomized controlled trial SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis TLR, toll-like receptor Th, T helper type iNOS, inducible nitric oxide synthase pDC, plasmacytoid dendritic cell AMP, antimicrobial peptide BD, β-defensin BMI, body mass index DC, dendritic cell DCD, dermcidin GSC, γ-secretase complex HS, hidradenitis suppurativa HiSCR, hidradenitis suppurativa clinical response IBD, inflammatory bowel disease IHS4, International Hidradenitis Suppurativa Severity Score System KC, keratinocyte MMP, matrix metalloproteinase NET, neutrophil extracellular traps NMSC, nonmelanoma skin cancer PG, pyoderma gangrenosum RCT, randomized controlled trial SAPHO, synovitis, acne, pustulosis, hyperostosis, and osteitis TLR, toll-like receptor Th, T helper type iNOS, inducible nitric oxide synthase pDC, plasmacytoid dendritic cell

来  源：   DOI：10.1016/j.xjidi.2021.100001   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1β, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis.
摘要：
化脓性汗腺炎（HS）是一种慢性皮肤炎症性疾病，复发缓解过程。该病的发病机制知之甚少，涉及多种因素，包括遗传学,环境,宿主-微生物相互作用，和免疫失调。特别是,皮肤微生物组的组成随着疾病的进展而变化，尽管尚不清楚这是主要还是次要过程。免疫调节治疗试验阐明了特异性免疫途径和细胞因子信号在疾病机制中的作用，如TNF-α，IL-1β,IL-12、IL-17、IL-23和补体。未来的研究应继续研究HS发病机理中微生物变化和免疫失调的原因和影响因素。
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