{Reference Type}: Journal Article
{Title}: Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.
{Author}: Jiang SW;Whitley MJ;Mariottoni P;Jaleel T;MacLeod AS;Jiang SW;Whitley MJ;Mariottoni P;Jaleel T;MacLeod AS;Jiang SW;Whitley MJ;Mariottoni P;Jaleel T;MacLeod AS;
{Journal}: JID Innov
{Volume}: 1
{Issue}: 1
{Year}: Mar 2021
暂无{DOI}: 10.1016/j.xjidi.2021.100001
{Abstract}: Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1β, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis.