PDF(Pubmed)
Abstract：
We aimed to investigate bidirectional associations between cognitive impairment and late age-related macular degeneration (AMD).
Participants in the Age-Related Eye Disease Study 2 (AREDS2) received annual eye examinations and cognitive function testing (e.g., Modified Telephone Interview for Cognitive Status [TICS-M]). We examined bidirectional associations between cognitive impairment (e.g., a TICS-M score < 30) and late AMD at 5 and 10 years.
Five thousand one hundred eighty-nine eyes (3157 participants; mean age 72.7 years) were analyzed and followed for a median of 10.4 years. Eyes of participants with cognitive impairment at baseline were more likely to progress to late AMD at 5 years (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.08-1.43) and 10 years (HR, 1.20; 95% CI, 1.05-1.37) than eyes of participants without cognitive impairment. Worse baseline AMD severity was not associated with developing cognitive impairment.
Cognitive impairment is associated with late AMD progression in AREDS2. Our finding highlights the importance of eyecare for people with cognitive impairment.
Participants in the Age-Related Eye Disease Study 2 (AREDS2) received annual eye examinations and cognitive function testing (e.g., Modified Telephone Interview for Cognitive Status [TICS-M]). We examined bidirectional associations between cognitive impairment (e.g., a TICS-M score < 30) and late AMD at 5 and 10 years.
Five thousand one hundred eighty-nine eyes (3157 participants; mean age 72.7 years) were analyzed and followed for a median of 10.4 years. Eyes of participants with cognitive impairment at baseline were more likely to progress to late AMD at 5 years (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.08-1.43) and 10 years (HR, 1.20; 95% CI, 1.05-1.37) than eyes of participants without cognitive impairment. Worse baseline AMD severity was not associated with developing cognitive impairment.
Cognitive impairment is associated with late AMD progression in AREDS2. Our finding highlights the importance of eyecare for people with cognitive impairment.
摘要：
我们旨在研究认知障碍与晚期年龄相关性黄斑变性（AMD）之间的双向关联。
年龄相关性眼病研究2（AREDS2）的参与者每年接受眼科检查和认知功能测试（例如，认知状态的修改电话访谈[TICS-M])。我们检查了认知障碍之间的双向关联(例如，TICS-M评分<30）和5年和10年的晚期AMD。
分析了五千一百八十九只眼睛（3157名参与者；平均年龄72.7岁），并随访中位数为10.4年。基线时患有认知障碍的参与者的眼睛在5年时更有可能发展为晚期AMD（风险比[HR]，1.24；95%置信区间[CI]，1.08-1.43)和10年(HR，1.20；95%CI，1.05-1.37)比没有认知障碍的参与者的眼睛。更糟糕的基线AMD严重程度与发展认知障碍无关。
在AREDS2中，认知障碍与AMD晚期进展相关。我们的发现强调了眼睛护理对认知障碍患者的重要性。
年龄相关性眼病研究2（AREDS2）的参与者每年接受眼科检查和认知功能测试（例如，认知状态的修改电话访谈[TICS-M])。我们检查了认知障碍之间的双向关联(例如，TICS-M评分<30）和5年和10年的晚期AMD。
分析了五千一百八十九只眼睛（3157名参与者；平均年龄72.7岁），并随访中位数为10.4年。基线时患有认知障碍的参与者的眼睛在5年时更有可能发展为晚期AMD（风险比[HR]，1.24；95%置信区间[CI]，1.08-1.43)和10年(HR，1.20；95%CI，1.05-1.37)比没有认知障碍的参与者的眼睛。更糟糕的基线AMD严重程度与发展认知障碍无关。
在AREDS2中，认知障碍与AMD晚期进展相关。我们的发现强调了眼睛护理对认知障碍患者的重要性。
