%0 Journal Article
%T Assessing bidirectional associations between cognitive impairment and late age-related macular degeneration in the Age-Related Eye Disease Study 2.
%A Le JT
%A Agrón E
%A Keenan TDL
%A Clemons TE
%A Brenowitz WD
%A Yaffe K
%A Chew EY
%A  
%J Alzheimers Dement
%V 18
%N 7
%D 07 2022 10
%M 34758100
%F 16.655
%R 10.1002/alz.12473
%X We aimed to investigate bidirectional associations between cognitive impairment and late age-related macular degeneration (AMD).<BR>Participants in the Age-Related Eye Disease Study 2 (AREDS2) received annual eye examinations and cognitive function testing (e.g., Modified Telephone Interview for Cognitive Status [TICS-M]). We examined bidirectional associations between cognitive impairment (e.g., a TICS-M score < 30) and late AMD at 5 and 10 years.<BR>Five thousand one hundred eighty-nine eyes (3157 participants; mean age 72.7 years) were analyzed and followed for a median of 10.4 years. Eyes of participants with cognitive impairment at baseline were more likely to progress to late AMD at 5 years (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.08-1.43) and 10 years (HR, 1.20; 95% CI, 1.05-1.37) than eyes of participants without cognitive impairment. Worse baseline AMD severity was not associated with developing cognitive impairment.<BR>Cognitive impairment is associated with late AMD progression in AREDS2. Our finding highlights the importance of eyecare for people with cognitive impairment.