使用 Spike 的适体功能化脂质纳米颗粒特异性递送 RNAi 以靶向 SARS - CoV - 2 : 临床病例研究中的强抗 Covid 药物。
关键词: RNAi SARS-CoV-2 antiviral aptamer inhalation lipid nanoparticles
Mesh : Adenosine Monophosphate / analogs & derivatives pharmacology Administration, Inhalation Adult Alanine / analogs & derivatives pharmacology Antiviral Agents / administration & dosage chemistry metabolism pharmacology Aptamers, Nucleotide / chemistry COVID-19 / pathology virology Cell Line Humans Liposomes / chemistry Lung / diagnostic imaging pathology Male Nanoparticles / chemistry Protein Domains / genetics RNA Interference RNA, Small Interfering / administration & dosage chemistry metabolism pharmacology Recombinant Proteins / biosynthesis isolation & purification metabolism SARS-CoV-2 / isolation & purification metabolism SELEX Aptamer Technique Severity of Illness Index Spike Glycoprotein, Coronavirus / antagonists & inhibitors genetics metabolism Viral Load / drug effects COVID-19 Drug Treatment
来 源:
DOI:10.1111/cbdd.13978
PDF(Pubmed)