PDF(Pubmed)
Abstract：
Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplastin, a cell recognition glycoprotein of the immunoglobulin superfamily that participates in synapse formation and function and calcium signaling. Data from animal models suggest a role for neuroplastin in pathways affected in neuropsychiatric and neurodegenerative diseases. Neuroplastin loss or disruption of molecular pathways related to neuronal processes has been linked to various neurological diseases, including dementia, schizophrenia, and Alzheimer\'s disease. Here, we review the molecular features of the cell recognition molecule neuroplastin, and its binding partners, which are related to neurological processes and involved in learning and memory. The emerging functions of neuroplastin may have implications for the treatment of diseases, particularly those of the nervous system.
摘要：
神经精神和神经退行性疾病的分子机制尚未得到充分阐明。对这些机制的详细了解可能有助于进一步改善医疗干预。最近,智力能力,创造力,健忘症与神经活酶有关，免疫球蛋白超家族的一种细胞识别糖蛋白，参与突触形成和功能以及钙信号传导。来自动物模型的数据表明神经激酶在神经精神和神经退行性疾病受影响的通路中的作用。与神经元过程相关的神经激酶丢失或分子通路的破坏与各种神经系统疾病有关。包括痴呆症,精神分裂症,和老年痴呆症。这里,我们回顾了细胞识别分子神经激酶的分子特征，及其具有约束力的合作伙伴，与神经过程有关，并参与学习和记忆。神经激酶的新功能可能对疾病的治疗有影响，尤其是那些神经系统。
