MicroRNA 调节的转录组分析确定了前列腺癌中具有预后和治疗意义的四种主要亚型。
关键词: ADT, androgen deprivation therapy AR, androgen receptor AUC, Area under the dose-response curve BCR, biochemical recurrence CAFs, cancer-associated fibroblasts CCLs, cancer cell lines CTLA-4, cytotoxic T-lymphocyte associated protein-4 DEmiRs, differentially expressed miRNAs DFS, disease-free survival EMT, epithelial-mesenchymal transition FDR, false discovery rate GEO, Gene Expression Omnibus GEP, gene expression profile GO, Gene Ontology GSEA, Gene Set Enrichment Analysis Heterogeneity ICB, immune checkpoint blockade IFN, interferon KEGG, Kyoto Encyclopedia of Genes and Genomes MDSCs, myeloid-derived suppressor cells MIRcor, miRNA-correlated Molecular subtypes NEPC, neuroendocrine prostate cancer NMF, non-negative matrix factorization NTP, Nearest template prediction OS, overall survival PCa, prostate cancer PD-1, programmed cell death protein-1 PD-L1, programmed death-ligand 1 Prostate cancer SCNAs, somatic copy number alterations SubMap, Subclass mapping TCGA, The Cancer Genome Atlas TGFβ, transforming growth factor β TMB, tumor mutation burden TNAs, tumor neoantigens Tregs, regulatory T cells k-NN, K-nearest neighbor mCRPC, metastatic castration-resistant prostate cancer miRNAs miRNAs, microRNAs ssGSEA, single-sample gene set enrichment analysis
来 源:
DOI:10.1016/j.csbj.2021.08.046
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