Mesh : Adult Amyloidosis / complications Analgesics, Opioid / adverse effects Autopsy Female Humans Injections, Intravenous Prescriptions Serum Amyloid A Protein Substance Abuse, Intravenous / complications

来  源:   DOI:10.1097/PAF.0000000000000718   PDF(Pubmed)

Abstract:
UNASSIGNED: There are reports of AA amyloidosis associated with intravenous and/or subcutaneous injection of street drugs, such as heroin and cocaine. Most reports describe patients with substance use disorder, renal amyloidosis and concurrent viral infections, such as hepatitis and/or human immunodeficiency virus. Herein, we present a case of systemic AA amyloidosis and sepsis in a 34-year-old woman with a history of intravenous injection of oral prescription medications (as evidenced by excipient lung disease) who had no known history of human immunodeficiency virus nor of hepatitis B or C. Our case shows the broader spectrum of pathology that can occur with the misuse of prescription medications.
摘要:
有报告说AA淀粉样变性与静脉注射和/或皮下注射街头毒品有关,比如海洛因和可卡因.大多数报告描述了物质使用障碍的患者,肾淀粉样变性和并发病毒感染,如肝炎和/或人类免疫缺陷病毒。在这里,我们介绍了一例34岁女性的全身性AA淀粉样变性和败血症病例,该女性有口服处方药静脉注射史(如赋形剂肺病所证明),该女性没有已知的人类免疫缺陷病毒史,也没有乙型肝炎或丙型肝炎史。
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