{Reference Type}: Case Reports {Title}: Systemic AA Amyloidosis Associated With Intravenous Injection of Oral Prescription Opioids-An Autopsy Case Report. {Author}: Zabel KM;Lin GY;Sell RE;Aisagbonhi O; {Journal}: Am J Forensic Med Pathol {Volume}: 43 {Issue}: 2 {Year}: Jun 2022 1 {Factor}: 1.108 {DOI}: 10.1097/PAF.0000000000000718 {Abstract}: UNASSIGNED: There are reports of AA amyloidosis associated with intravenous and/or subcutaneous injection of street drugs, such as heroin and cocaine. Most reports describe patients with substance use disorder, renal amyloidosis and concurrent viral infections, such as hepatitis and/or human immunodeficiency virus. Herein, we present a case of systemic AA amyloidosis and sepsis in a 34-year-old woman with a history of intravenous injection of oral prescription medications (as evidenced by excipient lung disease) who had no known history of human immunodeficiency virus nor of hepatitis B or C. Our case shows the broader spectrum of pathology that can occur with the misuse of prescription medications.