PDF(Pubmed)
Abstract：
Motilin, produced in endocrine cells in the mucosa of the upper intestine, is an important regulator of gastrointestinal (GI) motility and mediates the phase III of interdigestive migrating motor complex (MMC) in the stomach of humans, dogs and house musk shrews through the specific motilin receptor (MLN-R). Motilin-induced MMC contributes to the maintenance of normal GI functions and transmits a hunger signal from the stomach to the brain. Motilin has been identified in various mammals, but the physiological roles of motilin in regulating GI motility in these mammals are well not understood due to inconsistencies between studies conducted on different species using a range of experimental conditions. Motilin orthologs have been identified in non-mammalian vertebrates, and the sequence of avian motilin is relatively close to that of mammals, but reptile, amphibian and fish motilins show distinctive different sequences. The MLN-R has also been identified in mammals and non-mammalian vertebrates, and can be divided into two main groups: mammal/bird/reptile/amphibian clade and fish clade. Almost 50 years have passed since discovery of motilin, here we reviewed the structure, distribution, receptor and the GI motility regulatory function of motilin in vertebrates from fish to mammals.
摘要：
Motilin,在上肠粘膜的内分泌细胞中产生，是胃肠道（GI）运动的重要调节剂，并介导人类胃中消化间迁移运动复合体（MMC）的III期，狗和房子麝香通过特定的胃动素受体（MLN-R）。胃动素诱导的MMC有助于维持正常的GI功能，并将饥饿信号从胃传递到大脑。已经在各种哺乳动物中发现了胃动素，但是，由于使用一系列实验条件对不同物种进行的研究之间的不一致，胃动素在调节这些哺乳动物的胃肠道运动中的生理作用尚不清楚。已经在非哺乳动物脊椎动物中鉴定出胃动素直向同源物，鸟类胃动素的序列与哺乳动物的序列相对接近，但是爬行动物,两栖动物和鱼类图案显示出独特的不同序列。在哺乳动物和非哺乳动物脊椎动物中也发现了MLN-R。可分为两大类：哺乳动物/鸟类/爬行动物/两栖动物进化枝和鱼类进化枝。发现胃动素已经过去了近50年，这里我们回顾了结构，分布，从鱼类到哺乳动物的脊椎动物中胃动素的受体和胃肠道运动调节功能。
