PDF(Pubmed)
Abstract：
UNASSIGNED: Thyroid nodules are one of the most common entities that affect the thyroid gland. Traditionally, their treatment was surgery. Currently, ablation combination with percutaneous procedure became a good option.To analyze safety, efficacy, and describe our experience in microwave-ablation using ultrasound-guidance for benign thyroid nodules.A total of 304 patients with 1180 thyroid nodules (thyroid cystadenoma and nodular goiter) were studied retrospectively. Two hundred sixty-seven patients who underwent microwave-ablation successfully in our hospital were enrolled in this study. The baseline, follow-up nodule volume, thyroid function tests, thyroid antibodies, and posttherapy complications were analyzed. The informed written consent was obtained from patients or guardians. The study was approved by the ethics committee of our hospital.The average age was 50.1 ± 11.7 (21-83 years), 214 were women (80.1%) and 53 (19.9%) were men. The average number of nodules per patient was 4.02 ± 1.8 (1-8), 9.86%, 6.13%, and 84% located in the right thyroid lobe, left lobe, and bilateral, respectively. The average size of the nodules was 5.28 cm2 ± 3.63 (0.09-23.45 cm2). The average ablation time was 11 minutes ± 5.36 (3-20 minutes). The hospitalization period was 24 hours ± 10.16 (7-48 hours). Eighteen complications were reported. Postablation volume reduction rate was 54.74% and 93.3% at 3 and 12 months follow-up respectively (P < .05). The thyroid function tests, pre and postablation showed no significant changes (P > .05).Ultrasound-guided microwave-ablation of thyroid nodules is safe and effective. More clinical trials are needed to define the true use of microwave-ablation.
摘要：
未经授权：甲状腺结节是影响甲状腺的最常见实体之一。传统上,他们的治疗是手术。目前,消融结合经皮手术成为一个很好的选择。为了分析安全性，功效,并描述我们使用超声引导微波消融治疗良性甲状腺结节的经验。回顾性研究了304例患者，1180个甲状腺结节（甲状腺囊腺瘤和结节性甲状腺肿）。本研究纳入了在我院成功进行微波消融的两百六十七例患者。基线，随访结节体积，甲状腺功能检查,甲状腺抗体，并对治疗后并发症进行分析。获得患者或监护人的知情同意书。该研究获得了我院伦理委员会的批准。平均年龄为50.1±11.7（21-83岁），女性214人（80.1%），男性53人（19.9%）。平均每个患者的结节数为4.02±1.8(1-8),9.86%,6.13%，84%位于甲状腺右叶,左叶,和双边,分别。结节的平均大小为5.28cm2±3.63（0.09-23.45cm2）。平均消融时间为11分钟±5.36（3-20分钟）。住院时间为24小时±10.16（7-48小时）。报告了18例并发症。随访3个月和12个月时消融后体积减少率分别为54.74%和93.3%(P<0.05)。甲状腺功能检查,消融前后无明显变化(P>.05)。超声引导下微波消融甲状腺结节安全有效。需要更多的临床试验来定义微波消融的真正用途。
