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Abstract：
UNASSIGNED: Xanthogranulomatous pyelonephritis (XPGN) is a rare pathology of the kidneys occurring in 0.6 to 1% of all cases of renal infections, in both men and women. It is characterized by severe inflammation of the renal parenchyma leading to formation of granulomatous tissue containing lipid-laden macrophages. This condition may mimic less aggressive or benign conditions but may worsen or be fatal if not treated aggressively.
METHODS: Our patient is a 54 year old Caucasian female who presented with five days of left flank pain, hematuria, chills, nausea and vomiting. Imaging and biopsy results showed that the patient had XPGN.
UNASSIGNED: XPGN is a difficult condition to diagnose as the symptoms are non-specific relative to renal cell carcinoma or other common renal infections. Definitive diagnosis is made with a biopsy; however, clues in various imaging modalities are used to make a tentative diagnosis. It is unclear whether earlier surgical intervention would have improved overall patient outcomes. Currently, a partial or complete nephrectomy is the only effective treatment.
CONCLUSIONS: Aggressive management including early diagnosis, antibiotics and nephrectomy appears to be critical in preventing progression and complications of XPNG.
METHODS: Our patient is a 54 year old Caucasian female who presented with five days of left flank pain, hematuria, chills, nausea and vomiting. Imaging and biopsy results showed that the patient had XPGN.
UNASSIGNED: XPGN is a difficult condition to diagnose as the symptoms are non-specific relative to renal cell carcinoma or other common renal infections. Definitive diagnosis is made with a biopsy; however, clues in various imaging modalities are used to make a tentative diagnosis. It is unclear whether earlier surgical intervention would have improved overall patient outcomes. Currently, a partial or complete nephrectomy is the only effective treatment.
CONCLUSIONS: Aggressive management including early diagnosis, antibiotics and nephrectomy appears to be critical in preventing progression and complications of XPNG.
摘要：
未经证实：黄色肉芽肿性肾盂肾炎（XPGN）是一种罕见的肾脏病理，发生在所有肾脏感染病例的0.6％至1％，在男人和女人。其特征在于肾实质的严重炎症,导致含有脂质负载的巨噬细胞的肉芽肿组织的形成。这种情况可能模仿较不积极或良性的情况，但如果不积极治疗，可能会恶化或致命。
方法：我们的患者是一名54岁的白种人女性，表现为5天的左侧腹疼痛，血尿,发冷,恶心和呕吐。影像学和活检结果显示患者患有XPGN。
UASSIGNED：XPGN是一种难以诊断的疾病，因为症状相对于肾细胞癌或其他常见的肾脏感染是非特异性的。明确的诊断是通过活检;然而，各种成像方式中的线索用于进行初步诊断。目前尚不清楚早期手术干预是否会改善患者的总体预后。目前,部分或完全肾切除术是唯一有效的治疗方法。
结论：积极的管理，包括早期诊断，抗生素和肾切除术似乎对预防XPNG的进展和并发症至关重要。
方法：我们的患者是一名54岁的白种人女性，表现为5天的左侧腹疼痛，血尿,发冷,恶心和呕吐。影像学和活检结果显示患者患有XPGN。
UASSIGNED：XPGN是一种难以诊断的疾病，因为症状相对于肾细胞癌或其他常见的肾脏感染是非特异性的。明确的诊断是通过活检;然而，各种成像方式中的线索用于进行初步诊断。目前尚不清楚早期手术干预是否会改善患者的总体预后。目前,部分或完全肾切除术是唯一有效的治疗方法。
结论：积极的管理，包括早期诊断，抗生素和肾切除术似乎对预防XPNG的进展和并发症至关重要。
