Mesh : Adult China / epidemiology Cities / epidemiology Drug Resistance, Viral / genetics Female Genome, Viral / genetics Genotype HIV Infections / epidemiology virology HIV-1 / classification genetics isolation & purification Humans Male Mutation Phylogeny Recombination, Genetic pol Gene Products, Human Immunodeficiency Virus / genetics

来  源:   DOI:10.1007/s00705-021-05198-5

Abstract:
Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.
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