%0 Journal Article
%T Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China.
%A Lan Y
%A Li L
%A Cai W
%A Li J
%A Deng X
%A Li F
%A Lei C
%A Hu F
%A Tang X
%J Arch Virol
%V 166
%N 10
%D Oct 2021
%M 34373969
%F 2.685
%R 10.1007/s00705-021-05198-5
%X Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.