PDF(Pubmed)
Abstract：
Several plants have traditionally been used since antiquity to treat various gastroenteritis and respiratory symptoms similar to COVID-19 outcomes. The common symptoms of COVID-19 include fever or chills, cold, cough, flu, headache, diarrhoea, tiredness/fatigue, sore throat, loss of taste or smell, asthma, shortness of breath, or difficulty breathing, etc. This study aims to find out the plants and plant-derived products which are being used by the COVID-19 infected patients in Bangladesh and how those plants are being used for the management of COVID-19 symptoms. In this study, online and partially in-person survey interviews were carried out among Bangladeshi respondents. We selected Bangladeshi COVID-19 patients who were detected Coronavirus positive (+) by RT-PCR nucleic acid test and later recovered. Furthermore, identified plant species from the surveys were thoroughly investigated for safety and efficacy based on the previous ethnomedicinal usage reports. Based on the published data, they were also reviewed for their significant potentialities as antiviral, anti-inflammatory, and immunomodulatory agents. We explored comprehensive information about a total of 26 plant species, belonging to 23 genera and 17 different botanical families, used in COVID-19 treatment as home remedies by the respondents. Most of the plants and plant-derived products were collected directly from the local marketplace. According to our survey results, greatly top 5 cited plant species measured as per the highest RFC value are Camellia sinensis (1.0) > Allium sativum (0.984) > Azadirachta indica (0.966) > Zingiber officinale (0.966) > Syzygium aromaticum (0.943). Previously published ethnomedicinal usage reports, antiviral, anti-inflammatory, and immunomodulatory activity of the concerned plant species also support our results. Thus, the survey and review analysis simultaneously reveals that these reported plants and plant-derived products might be promising candidates for the treatment of COVID-19. Moreover, this study clarifies the reported plants for their safety during COVID-19 management and thereby supporting them to include in any future pre-clinical and clinical investigation for developing herbal COVID-19 therapeutics.
摘要：
自古以来，传统上使用几种植物治疗各种胃肠炎和类似于COVID-19结果的呼吸道症状。COVID-19的常见症状包括发烧或寒战，冷,咳嗽,流感,头痛,腹泻,疲倦/疲劳,喉咙痛,失去味道或气味，哮喘,呼吸急促,或者呼吸困难,等。这项研究旨在找出孟加拉国感染COVID-19的患者正在使用的植物和植物衍生产品，以及这些植物是如何用于治疗COVID-19症状的。在这项研究中,在孟加拉国受访者中进行了在线和部分面对面调查访谈.我们选择了孟加拉国COVID-19患者，这些患者通过RT-PCR核酸检测检测出冠状病毒阳性（+），后来康复。此外，根据以前的种族医学使用报告，对调查中确定的植物物种的安全性和有效性进行了彻底调查。根据公布的数据,还审查了它们在抗病毒方面的巨大潜力，抗炎,和免疫调节剂。我们探索了总共26种植物的综合信息，属于23属和17个不同的植物科，受访者在COVID-19治疗中用作家庭疗法。大多数植物和植物衍生产品是直接从当地市场收集的。根据我们的调查结果,按最高RFC值测量的前5种引用植物为山茶（1.0）>葱（0.984）>印染（0.966）>生姜（0.966）>香菇（0.943）。以前发表的种族医学使用报告，抗病毒，抗炎,有关植物物种的免疫调节活性也支持我们的结果。因此，调查和审查分析同时表明，这些报告的植物和植物衍生产品可能是治疗COVID-19的有希望的候选药物。此外，这项研究澄清了报道的植物在COVID-19管理过程中的安全性，从而支持它们在未来的任何临床前和临床研究中纳入，以开发草药COVID-19疗法。
