Mesh : Anti-Bacterial Agents / pharmacology therapeutic use Child Child, Preschool Febrile Neutropenia / drug therapy microbiology Female Hematopoietic Stem Cell Transplantation / adverse effects Humans Leukemia / complications microbiology Male Microbial Sensitivity Tests Practice Guidelines as Topic Prospective Studies Streptococcal Infections / drug therapy Vancomycin / therapeutic use Viridans Streptococci / drug effects

来  源:   DOI:10.1097/INF.0000000000003210

Abstract:
Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. Of 19 VGS bacteremia episodes, 78.9% were susceptible to risk-stratified antibiotics including 100% from high-risk patients. All blood cultures were flagged positive within 24 hours.
摘要:
Viridans群链球菌(VGS)是免疫抑制儿童败血症的重要原因。我们回顾了在107例白血病或接受同种异体移植的儿童中,风险分层添加万古霉素用于经验性发热性中性粒细胞减少症治疗的有效性。在19次VGS菌血症发作中,78.9%的人对危险分层的抗生素敏感,其中100%来自高危患者。所有血液培养物在24小时内被标记为阳性。
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