Mesh : Animals Cachexia / metabolism Gluconeogenesis Liver / metabolism Melanoma / metabolism Zebrafish

来  源:   DOI:10.1016/j.trecan.2021.06.006   PDF(Sci-hub)

Abstract:
The mechanism of metabolic crosstalk between different tissues in the host remains poorly understood but is likely to play important roles in tumor growth and cachexia. A recent study from Naser, Jackstadt, et al. utilizes isotope tracing in a zebrafish melanoma model and finds that tumors secrete alanine into circulation, which is taken up by the liver and used for gluconeogenesis.
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