PDF(Pubmed)
Abstract：
UNASSIGNED: Any single discrete blood pressure (BP) measurement is not enough to estimate adverse cardiovascular events. We aim to comprehensively investigate the association between BP indicators and stroke.
UNASSIGNED: An observational cohort study was conducted among 2888 Shanghai community-aged residents from 2014 to 2018, and a nested case-control study was designed to identify the association between BP indicators and stroke. In total 415 cases of stroke detected during the study period were selected as the case group and 415 non-stroke subjects, matched with factors of age and gender, were randomly selected from the cohort as control group.
UNASSIGNED: Multivariate logistic regression analysis revealed that systolic blood pressure (SBP) (adjusted odds ratio [AOR] 1.02, 95% confidence interval [CI] 1.02-1.03), pulse pressure (PP) (AOR 1.03, 95% CI 1.02-1.04), mean arterial pressure (MAP) (AOR1.02, 95% CI 1.01-1.04) and pulse pressure index (PPI) (AOR 25.68, 95% CI 3.19-206.90) increased the risk of stroke, respectively. After fitting both BP indicators and covariates, isolated abnormal SBP (AOR 2.55, 95% CI 1.74-3.72) or PP ≥50 mmHg (AOR 1.66, 95% CI 1.08-2.56) independently increased risk of stroke.
UNASSIGNED: Besides SBP, PP and multiple factors, assessment should be taken into account comprehensively for stroke prevention and management.
UNASSIGNED: An observational cohort study was conducted among 2888 Shanghai community-aged residents from 2014 to 2018, and a nested case-control study was designed to identify the association between BP indicators and stroke. In total 415 cases of stroke detected during the study period were selected as the case group and 415 non-stroke subjects, matched with factors of age and gender, were randomly selected from the cohort as control group.
UNASSIGNED: Multivariate logistic regression analysis revealed that systolic blood pressure (SBP) (adjusted odds ratio [AOR] 1.02, 95% confidence interval [CI] 1.02-1.03), pulse pressure (PP) (AOR 1.03, 95% CI 1.02-1.04), mean arterial pressure (MAP) (AOR1.02, 95% CI 1.01-1.04) and pulse pressure index (PPI) (AOR 25.68, 95% CI 3.19-206.90) increased the risk of stroke, respectively. After fitting both BP indicators and covariates, isolated abnormal SBP (AOR 2.55, 95% CI 1.74-3.72) or PP ≥50 mmHg (AOR 1.66, 95% CI 1.08-2.56) independently increased risk of stroke.
UNASSIGNED: Besides SBP, PP and multiple factors, assessment should be taken into account comprehensively for stroke prevention and management.
摘要：
■任何单个离散血压（BP）测量都不足以估计不良心血管事件。我们旨在全面调查血压指标与卒中之间的关系。
■于2014年至2018年在2888名上海社区老年居民中进行了一项观察性队列研究，并设计了一项巢式病例对照研究，以确定BP指标与卒中之间的关系。在研究期间共检测到415例中风病例作为病例组，并选择415例非中风受试者。与年龄和性别因素相匹配，从队列中随机选择作为对照组。
■多因素logistic回归分析显示收缩压（SBP）（调整比值比[AOR]1.02，95%置信区间[CI]1.02-1.03），脉压（PP）（AOR1.03，95%CI1.02-1.04），平均动脉压（MAP）（AOR1.02，95％CI1.01-1.04）和脉压指数（PPI）（AOR25.68，95％CI3.19-206.90）增加了中风的风险，分别。在拟合BP指标和协变量后，孤立性异常SBP(AOR2.55,95%CI1.74-3.72)或PP≥50mmHg(AOR1.66,95%CI1.08-2.56)独立增加卒中风险.
■除了SBP，PP和多个因素，中风的预防和管理应综合考虑评估。
■于2014年至2018年在2888名上海社区老年居民中进行了一项观察性队列研究，并设计了一项巢式病例对照研究，以确定BP指标与卒中之间的关系。在研究期间共检测到415例中风病例作为病例组，并选择415例非中风受试者。与年龄和性别因素相匹配，从队列中随机选择作为对照组。
■多因素logistic回归分析显示收缩压（SBP）（调整比值比[AOR]1.02，95%置信区间[CI]1.02-1.03），脉压（PP）（AOR1.03，95%CI1.02-1.04），平均动脉压（MAP）（AOR1.02，95％CI1.01-1.04）和脉压指数（PPI）（AOR25.68，95％CI3.19-206.90）增加了中风的风险，分别。在拟合BP指标和协变量后，孤立性异常SBP(AOR2.55,95%CI1.74-3.72)或PP≥50mmHg(AOR1.66,95%CI1.08-2.56)独立增加卒中风险.
■除了SBP，PP和多个因素，中风的预防和管理应综合考虑评估。
