病理学的最新进展 : “病理学杂志 ” 2021 年年度评论。
关键词: 3D culture CSC niche DNA damage GWAS HDAC inhibitors IL-33 KAP1 MAPK MDM2 PD-1 PD-L1 Smad TGF-β TIF1beta TRIM28 Wilms' tumour acute respiratory distress syndrome (ARDS) angiotensin-converting enzyme 2 (ACE2) antifibrotic atezolizumab autoimmunity bone cancer cancer predisposition cancer progression cancer stem cells (CSCs) cell of origin cellular crosstalk chromatin modification coronavirus disease 2019 (COVID-19) damage-associated molecular patterns diffuse alveolar damage (DAD) direct-to-consumer drug development drug resistance dysbiosis embryonic kidney development endothelial to mesenchymal transition (endMT) epigenetics epithelial to mesenchymal transition (EMT) extracellular matrix gene enhancers genetic diagnosis genetics genomics human genetics idiopathic pulmonary fibrosis immuno-oncology immunopathology immunotherapy inflammation intratumoral microbiota ipilimumab local microbiota mTOR macrophages metabolomics microbial metabolites microbial toxins microbiome microstructure migration mitochondrial disease mitochondrial pathology mouse model multiplex immunohistochemistry multiplex in situ hybridization nephroblastoma nivolumab oncogene organoids p53 p63 pathology pathophysiology pembrolizumab phagocytosis polarization polygenic risk score precision medicine profibrotic proteomics sarcoma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shear stress single cell transcriptomes soft tissue spatial transcriptomics squamous cell cancer stem cells stiffness stretch therapeutic discovery therapy treatment tumorigenesis tumour microenvironment tumour suppressor tumour-infiltrating lymphocytes
Mesh : COVID-19 / genetics pathology virology Genomics / methods Humans Neoplasms / complications genetics pathology Organoids / pathology SARS-CoV-2 / pathogenicity United Kingdom
来 源:
DOI:10.1002/path.5687
PDF(Sci-hub)