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Abstract：
BACKGROUND: Pre-Exposure Prophylaxis (PrEP) is a biomedical intervention to prevent HIV infection in seronegative people at high risk of becoming infected. This strategy was endorsed in October 2019 by the Spanish Ministry of Health.
OBJECTIVE: To present the PrEP initial experience in the HIV Unit of the Hospital Clínic of Barcelona, paying special attention to the analysis of the vulnerability factors in the cohort.
METHODS: Retrospective, descriptive study. The epidemiological, sociodemographic, and clinical characteristics of the users included in the program during the first year are analyzed, paying particular attention to Infections, risky practices, and substance use.
RESULTS: 190 individuals were included, 177 men and 12 trans women with a mean age of 35 years (8 SD). 70% had higher education, and half had Spanish nationality. An average of 10 couples per trimester and 60% reported unprotected anal sex. 31% had at least one positive PCR for STIs, with N. gonorrhoeae being the most prevalent microorganism (51%) and the rectal sample the most affected (21%). 63% reported chemsex use, 19% polydrug use, and 8% \"slamming\". Half expressed concern about consumption and/or sexual practices and 25% the need for help.
CONCLUSIONS: The PrEP user profile attended in our Hospital Unit justifies the creation of multidisciplinary teams that allow us to provide holistic attention to the sexual life of these people.
OBJECTIVE: To present the PrEP initial experience in the HIV Unit of the Hospital Clínic of Barcelona, paying special attention to the analysis of the vulnerability factors in the cohort.
METHODS: Retrospective, descriptive study. The epidemiological, sociodemographic, and clinical characteristics of the users included in the program during the first year are analyzed, paying particular attention to Infections, risky practices, and substance use.
RESULTS: 190 individuals were included, 177 men and 12 trans women with a mean age of 35 years (8 SD). 70% had higher education, and half had Spanish nationality. An average of 10 couples per trimester and 60% reported unprotected anal sex. 31% had at least one positive PCR for STIs, with N. gonorrhoeae being the most prevalent microorganism (51%) and the rectal sample the most affected (21%). 63% reported chemsex use, 19% polydrug use, and 8% \"slamming\". Half expressed concern about consumption and/or sexual practices and 25% the need for help.
CONCLUSIONS: The PrEP user profile attended in our Hospital Unit justifies the creation of multidisciplinary teams that allow us to provide holistic attention to the sexual life of these people.
摘要：
背景：暴露前预防（PrEP）是一种生物医学干预措施，用于预防血清阴性人群感染艾滋病毒的高风险感染。该战略于2019年10月得到西班牙卫生部的认可。
目的：介绍在巴塞罗那医院ClínicHIV部门的PrEP初步经验，特别注意队列中脆弱性因素的分析。
方法：回顾性，描述性研究。流行病学,社会人口统计学，并分析第一年计划中包含的用户的临床特征，特别注意感染，冒险的做法，和物质使用。
结果：纳入190人，177名男性和12名跨性别女性，平均年龄为35岁（8SD）。70%受过高等教育，一半有西班牙国籍.平均每三个月有10对夫妇和60％的人报告无保护的肛交。31%的人至少有一次性传播感染的PCR阳性，淋病奈瑟菌是最普遍的微生物(51%)，直肠样本受影响最大(21%)。63%的人报告使用化学药物，19％的多药物使用，和8%的“猛烈抨击”。一半的人表示担心消费和/或性行为，25%的人表示需要帮助。
结论：在我们医院部门参加的PrEP用户简介证明了多学科团队的建立是合理的，使我们能够全面关注这些人的性生活。
目的：介绍在巴塞罗那医院ClínicHIV部门的PrEP初步经验，特别注意队列中脆弱性因素的分析。
方法：回顾性，描述性研究。流行病学,社会人口统计学，并分析第一年计划中包含的用户的临床特征，特别注意感染，冒险的做法，和物质使用。
结果：纳入190人，177名男性和12名跨性别女性，平均年龄为35岁（8SD）。70%受过高等教育，一半有西班牙国籍.平均每三个月有10对夫妇和60％的人报告无保护的肛交。31%的人至少有一次性传播感染的PCR阳性，淋病奈瑟菌是最普遍的微生物(51%)，直肠样本受影响最大(21%)。63%的人报告使用化学药物，19％的多药物使用，和8%的“猛烈抨击”。一半的人表示担心消费和/或性行为，25%的人表示需要帮助。
结论：在我们医院部门参加的PrEP用户简介证明了多学科团队的建立是合理的，使我们能够全面关注这些人的性生活。
