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Abstract：
Anxiety disorders are highly prevalent and cause substantial personal, social and economic burden. Altered attentional control has been shown to be present across anxiety disorders and is associated with specific changes in brain activity which can be recorded by electroencephalogram (EEG). These include changes in the EEG markers of error-related negativity (ERN) and correct-response negativity (CRN), both believed to reflect response monitoring and attentional control pathophysiology in anxiety. The aim of this review was to systematically assess the research on ERN and CRN in attentional control in individuals with clinical anxiety and healthy controls, across emotional and non-emotional attentional control.
A comprehensive literature search was conducted for studies published prior to October 22nd, 2020. Details of the protocol for this systematic review were registered on PROSPERO (CRD42019144885).
66 studies had their data extracted. All 66 studies measured ERN, with 85% finding significantly increased ERN amplitudes associated with clinical anxiety. Only 44 of the extracted studies analysed CRN and only ~20% of these found significant changes in CRN amplitude associated with individuals with clinical anxiety.
There were several anxiety disorders that had either limited literature (i.e. specific phobia, separation anxiety disorder or agoraphobia) or nil literature (i.e. selective mutism) available. No extracted studies included samples of older adults (i.e. aged 60+ years), and only six extracted studies included measures of emotional attentional control.
Findings indicate the promising utility of ERN of attentional control as a robust, transdiagnostic trait marker of clinical anxiety.
A comprehensive literature search was conducted for studies published prior to October 22nd, 2020. Details of the protocol for this systematic review were registered on PROSPERO (CRD42019144885).
66 studies had their data extracted. All 66 studies measured ERN, with 85% finding significantly increased ERN amplitudes associated with clinical anxiety. Only 44 of the extracted studies analysed CRN and only ~20% of these found significant changes in CRN amplitude associated with individuals with clinical anxiety.
There were several anxiety disorders that had either limited literature (i.e. specific phobia, separation anxiety disorder or agoraphobia) or nil literature (i.e. selective mutism) available. No extracted studies included samples of older adults (i.e. aged 60+ years), and only six extracted studies included measures of emotional attentional control.
Findings indicate the promising utility of ERN of attentional control as a robust, transdiagnostic trait marker of clinical anxiety.
摘要：
焦虑症是非常普遍的，并导致大量的个人，社会和经济负担。已显示，在焦虑症中存在改变的注意力控制，并且与可以通过脑电图（EEG）记录的大脑活动的特定变化有关。这些包括错误相关负性（ERN）和正确反应负性（CRN）的EEG标记的变化，两者都被认为反映了焦虑的反应监测和注意控制病理生理学。这篇综述的目的是系统评估ERN和CRN在临床焦虑个体和健康对照者注意控制中的研究。跨越情绪和非情绪注意力控制。
对10月22日之前发表的研究进行了全面的文献检索，2020年。本系统评价方案的详细信息已在PROSPERO（CRD42019144885）上注册。
66项研究提取了数据。所有66项研究都测量了ERN，85%发现与临床焦虑相关的ERN振幅显着增加。提取的研究中只有44项分析了CRN，其中只有约20％发现与临床焦虑患者相关的CRN振幅发生了显着变化。
有几种焦虑症的文献有限（即特定的恐惧症，分离焦虑症或广场恐惧症）或无文献（即选择性mutism）可用。没有提取的研究包括老年人(即60岁以上)的样本，只有六项提取的研究包括情绪注意控制的测量。
研究结果表明，注意力控制的ERN作为一种稳健的，临床焦虑的诊断特征标记。
对10月22日之前发表的研究进行了全面的文献检索，2020年。本系统评价方案的详细信息已在PROSPERO（CRD42019144885）上注册。
66项研究提取了数据。所有66项研究都测量了ERN，85%发现与临床焦虑相关的ERN振幅显着增加。提取的研究中只有44项分析了CRN，其中只有约20％发现与临床焦虑患者相关的CRN振幅发生了显着变化。
有几种焦虑症的文献有限（即特定的恐惧症，分离焦虑症或广场恐惧症）或无文献（即选择性mutism）可用。没有提取的研究包括老年人(即60岁以上)的样本，只有六项提取的研究包括情绪注意控制的测量。
研究结果表明，注意力控制的ERN作为一种稳健的，临床焦虑的诊断特征标记。
