目的:“亚综合征”强迫症症状(OCDS)很常见,会导致心理社会功能受损。OCDS可以通过心理病理学的维度模型更好地捕获,而不是分类诊断。然而,这种维度方法需要对潜在的神经认知驱动因素以及冲动和强迫特征有深刻的理解(即,神经认知表型)跨症状。这项研究调查了冲动性的抑制控制和自我监测,强迫性,以及它们在经历轻度-中度OCDS的个体(n=40)中的相互作用。
方法:脑电图记录与停止信号任务同时用于引出事件相关电位(ERPs)索引抑制控制(即,N2和P3)和自我监测(即,错误相关的消极和正确相关的消极(CRN):错误或正确的反应后的消极,分别)。
结果:在不成功的停止过程中,冲动性和强迫性高的个体表现出增强的N2振幅,指示反应的冲动和需要停止之间的冲突(F(3,33)=1.48,P<.05,95%Cl[-0.01,0.001])。强迫性高和冲动性低的个体显示出降低的P3振幅,与监测失败的抑制控制中的损伤一致(F(3,24)=2.033,P<.05,95%CI[-0.002,0.045])。成功停止后,高强迫性(与冲动性无关)与较低的CRN振幅相关,反映了对正确反应的低监测(F(4,32)=4.76,P<.05,95%CI[0.01,0.02]),并且OCDS严重程度更高(F(3,36)=3.32,P<.05,95%CI[0.03,0.19])。
结论:当前的发现为差异提供了证据,OCDS中脉冲和强迫性表型的ERP索引抑制控制和自我监测概况。
\"Subsyndromal\" obsessive-compulsive disorder symptoms (OCDSs) are common and cause impaired psychosocial functioning. OCDSs are better captured by dimensional models of psychopathology, as opposed to categorical diagnoses. However, such dimensional approaches require a deep understanding of the underlying neurocognitive drivers and impulsive and compulsive traits (ie, neurocognitive phenotypes) across symptoms. This study investigated inhibitory control and self-monitoring across impulsivity, compulsivity, and their interaction in individuals (n = 40) experiencing mild-moderate OCDSs.
EEG recording concurrent with the stop-signal task was used to elicit event-related potentials (ERPs) indexing inhibitory control (ie, N2 and P3) and self-monitoring (ie, error-related negativity and correct-related negativity (
CRN): negativity following erroneous or correct responses, respectively).
During unsuccessful stopping, individuals high in both impulsivity and compulsivity displayed enhanced N2 amplitude, indicative of conflict between the urge to respond and need to stop (F(3, 33) = 1.48, P < .05, 95% Cl [-0.01, 0.001]). Individuals high in compulsivity and low in impulsivity showed reduced P3 amplitude, consistent with impairments in monitoring failed inhibitory control (F(3, 24) = 2.033, P < .05, 95% CI [-0.002, 0.045]). Following successful stopping, high compulsivity (independent of impulsivity) was associated with lower
CRN amplitude, reflecting hypo-monitoring of correct responses (F(4, 32) = 4.76, P < .05, 95% CI [0.01, 0.02]), and with greater OCDS severity (F(3, 36) = 3.32, P < .05, 95% CI [0.03, 0.19]).
The current findings provide evidence for differential, ERP-indexed inhibitory control and self-monitoring profiles across impulsive and compulsive phenotypes in OCDSs.