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Abstract：
Coenzyme Q (CoQ) is an important component of the mitochondrial electron transport chain. The finding that multiple chronic diseases show lower levels of CoQ10 has led to the possibility that CoQ10 supplementation could be an effective approach to ameliorate or prevent disease progression. In this review, we discuss the state of the art regarding the role of CoQ10 in health and disease and describe the latest clinical studies which have tested the effects of CoQ10 supplementation in inflammatory diseases. The results of these studies indicate that individuals suffering from inflammation-related diseases show improvement under the CoQ10 supplementation protocol. However, these results have been inconsistent, leading to the need for additional studies at the preclinical and clinical levels, involving a greater number of subjects and different treatment regimes.
摘要：
辅酶Q(CoQ)是线粒体电子传递链的重要构成部门。多种慢性疾病显示CoQ10水平较低的发现导致补充CoQ10可能是改善或预防疾病进展的有效方法。在这次审查中,我们讨论了CoQ10在健康和疾病中的作用，并描述了最新的临床研究，这些研究测试了CoQ10补充剂在炎症性疾病中的作用。这些研究的结果表明，患有炎症相关疾病的个体在CoQ10补充方案下表现出改善。然而,这些结果不一致，导致需要在临床前和临床水平进行额外的研究，涉及更多的受试者和不同的治疗方案。
