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Abstract：
BACKGROUND: Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow-up periods are growing longer, the rate of unusual visceral metastases may increase.
METHODS: A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow-up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow-up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma.
CONCLUSIONS: We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long-term follow-up.
METHODS: A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow-up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow-up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma.
CONCLUSIONS: We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long-term follow-up.
摘要：
背景：转移性肾细胞癌的治疗方案多种多样。随着结果的改善和随访时间的延长，异常内脏转移的发生率可能会增加。
方法：一名68岁的男子被诊断为肺部，胰腺,左肾部分切除术后9年肾转移，诊断为pT1a透明细胞肾细胞癌开始使用舒尼替尼进行分子靶向治疗。靶向治疗开始九年后，随访计算机断层扫描显示食道肿块病变，并对食管转移灶进行内镜下黏膜切除术。一年后,通过随访计算机断层扫描检测到膀胱肿瘤.患者接受了经尿道膀胱肿瘤切除术。两个切除标本的组织学评估均显示透明细胞肾细胞癌。
结论：我们在长期随访中提出了一个有价值的肾细胞癌异时食管和膀胱转移病例。
方法：一名68岁的男子被诊断为肺部，胰腺,左肾部分切除术后9年肾转移，诊断为pT1a透明细胞肾细胞癌开始使用舒尼替尼进行分子靶向治疗。靶向治疗开始九年后，随访计算机断层扫描显示食道肿块病变，并对食管转移灶进行内镜下黏膜切除术。一年后,通过随访计算机断层扫描检测到膀胱肿瘤.患者接受了经尿道膀胱肿瘤切除术。两个切除标本的组织学评估均显示透明细胞肾细胞癌。
结论：我们在长期随访中提出了一个有价值的肾细胞癌异时食管和膀胱转移病例。
